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    2019年, 第14卷, 第6期 刊出日期:2019-12-20 上一期   
    Regular Article
    Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer
    Zhikang Duan, Han Zhang, Peng Zhao, Zhiyang Yan, Xiaoxiao Huang
    2019 (6):  253-259. 
    摘要 ( 35 )   PDF(1448KB) ( 61 )  
    Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets. Peperomia dindygulensis, belonging to Piperaceae family, was proved to be effective to the treatment of cancer, but the action mechanism is incomprehensive. In this study, we employed molecular docking and network pharmacology methods to predict the effective compositions, potential target proteins and potential biological pathways. Six compounds were predicted to have potential activity for liver-cancer target proteins. Meanwhile, we analyzed the biological pathways based on compounds-target network, which may be play an important role in liver cancer. This article is presented to explore the active ingredients of P. dindygulensis and provide crucial material for the further research and development of the plant.
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    Virtual screening of active ingredients, potential targets and pathways from Elephantopus scaber L. against liver cancer based on network pharmacology
    Shuhui Dong, Ming Bai, Xiaoxiao Huang, Shaojiang Song
    2019 (6):  260-267. 
    摘要 ( 25 )   PDF(1953KB) ( 33 )  
    Elephantopus scaber L., belonging to Elephantopus plant of Compositae, is widely used as the common Chinese herbal medicine in folk. According to the phytochemical investigations, E. scaber is used to treat several cancers, anemia and diarrhea on account of the property of the complex components and multi-targets. However, the underlying molecular mechanisms of herb remain unclear. In this report, network pharmacology method is used to analyze the relation among the small-molecule compounds of E. scaber, target proteins, biological pathways and liver cancer. The potential active compounds from the E. scaber, potential target proteins and the key pathways were predicted by network pharmacology models. We believe that our present study is useful to find novel lead compounds for liver cancer.
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    The progress and related pharmacological mechanism of hyperlipidemia treatment
    Zhaohui Ren, Jianxiu Zhai, Na Han, Zhihui Liu, Jun Yin
    2019 (6):  268-279. 
    摘要 ( 55 )   PDF(619KB) ( 41 )  
    Hyperlipidemia (HLP) is a long-known risk factor for a series of cardiovascular and cerebrovascular diseases, such as atherosclerosis, coronary heart disease, hypertension and so on. With its increasing incidence, the prevention and treatment of HLP has also become an important research topic around the world. Traditional Chinese medicine (TCM) has been used to treat HLP for a long time with its better therapeutic efficacy, less side effects and wider indications compared with western medicine. In this review, we summarized the pathogenesis of HLP, the research situation of disease-related targets, and the treatment progress of TCM by conducting literature research and sorting out relevant information, in order to provide reference for further research of HLP and prevent the occurrence of cardiovascular and cerebrovascular diseases.
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    Licorice and its main components on the treatment of diabetes and its complications: A review of in vivo and in vitro studies
    Lina Cheng, Shijie Cao, Ming Qu, Ning Kang
    2019 (6):  280-294. 
    摘要 ( 59 )   PDF(964KB) ( 31 )  
    Licorice is one of the oldest herbal medicines for its various ethno pharmacological uses. In both Asian and European countries, it has been recorded for treatment of inflammatory diseases. A large number of ingredients have been isolated from licorice, including triterpene saponins and flavonoids, which are normally being considered to be the main biologically active components. In the last decade, licorice has been proved exert anti-diabetic effect in various in vivo and in vitro models of diabetes mellitus. Furthermore, licorice can also antagonize all sorts of diabetes complications, including diabetic nephropathy, atherosclerosis, diabetic retinopathy and neuropathy. Except anti-inflammation, licorice and its active components show anti-diabetic effects by improving insulin resistance and increasing insulin secretion, regulating lipid metabolism, and anti-oxidation. The useful effects of licorice and its active components are due to regulating different pathways and proteins, including NF-κB, AMPK, insulin signaling pathway, MAPK, etc. In this review, we provide an overview of the beneficial effects and related molecular mechanism of licorice and its effective components on improving diabetes and its complications.
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    Research review in the main chemical components and biological activities of Daphne aurantiaca Diels
    Yangyang Zhang, Zhiyang Yan, Hao Zhang, Guodong Yao, Xiaoxiao Huang
    2019 (6):  295-302. 
    摘要 ( 32 )   PDF(1339KB) ( 48 )  
    Daphne aurantiaca Diels belongs to the Daphne L. genus of Thymelaeaceaen family and flavonoids, terpenoids, lignans, phenylpropanoids are the main chemical components isolated from this plant. And the extracts of Daphne aurantiaca Diels have been reported with multiple pharmacological activities and good development prospects, which have drawn enormous attention. Hence, this review summarized the research progress on the chemical components and the pharmacological effects of Daphne aurantiaca Diels.
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