Network pharmacology-based virtual screening of 
natural products from Peperomia dindygulensis
for the application to treat liver cancer

亚洲传统医药 ›› 2019, Vol. 14 ›› Issue (6): 253-259.

• Regular Article • 下一篇

Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer

Zhikang Duan, Han Zhang, Peng Zhao, Zhiyang Yan, Xiaoxiao Huang*

Department of Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China

收稿日期:2018-12-05 接受日期:2019-01-28 出版日期:2019-12-20 发布日期:2020-01-02

Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer

Zhikang Duan, Han Zhang, Peng Zhao, Zhiyang Yan, Xiaoxiao Huang*

Department of Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2018-12-05 Accepted:2019-01-28 Online:2019-12-20 Published:2020-01-02
Contact: School of Traditional Chinese Materia, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Tel.:+86-24-23986486; Fax: +86-24-23986486.

摘要/Abstract

摘要： Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets. Peperomia dindygulensis, belonging to Piperaceae family, was proved to be effective to the treatment of cancer, but the action mechanism is incomprehensive. In this study, we employed molecular docking and network pharmacology methods to predict the effective compositions, potential target proteins and potential biological pathways. Six compounds were predicted to have potential activity for liver-cancer target proteins. Meanwhile, we analyzed the biological pathways based on compounds-target network, which may be play an important role in liver cancer. This article is presented to explore the active ingredients of P. dindygulensis and provide crucial material for the further research and development of the plant.

关键词: Peperomia dindygulensis, network pharmacology, potential target, biological pathway

Abstract: Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets. Peperomia dindygulensis, belonging to Piperaceae family, was proved to be effective to the treatment of cancer, but the action mechanism is incomprehensive. In this study, we employed molecular docking and network pharmacology methods to predict the effective compositions, potential target proteins and potential biological pathways. Six compounds were predicted to have potential activity for liver-cancer target proteins. Meanwhile, we analyzed the biological pathways based on compounds-target network, which may be play an important role in liver cancer. This article is presented to explore the active ingredients of P. dindygulensis and provide crucial material for the further research and development of the plant.

Key words: Peperomia dindygulensis, network pharmacology, potential target, biological pathway

Zhikang Duan, Han Zhang, Peng Zhao, Zhiyang Yan, Xiaoxiao Huang. Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer[J]. 亚洲传统医药, 2019, 14(6): 253-259.

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Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer

Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer

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