亚洲传统医药
亚洲传统医药

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›› 2008, Vol. 3 ›› Issue (6): 203-210.

• 论文 •    下一篇

A first new antimalarial pregnane glycoside from Gongronema napalense

  

  • 收稿日期:2008-02-29 修回日期:2008-05-08 出版日期:2008-12-15 发布日期:2008-12-15

A first new antimalarial pregnane glycoside from Gongronema napalense

Amey Libman 1,2; Hongjie Zhang 1,*; Cuiying Ma 1,3; Bounhong Southavong 4; Kongmany Sydara 4; Somsanith Bouamanivong 4; Ghee T. Tan 1,5; Harry H. S. Fong 1; D. Doel Soejarto 1,*   

  1. 1. Program for Collaborative Research in the Pharmaceutical Sciences, M/C 781, Department of Medical Chemistry & Pharmacognosy, College of Pharmacy, the University of Illinois, Chicago, Illinois 60612, USA 2. Biology Department, Bradly University, Peoria, IL 61625, USA 3. Department of Reference Standard Evaluation, U. S. Pharmacopeia, Rockville, MD 20852, USA 4. Traditional Medicine Research Center (TMRC), Ministry of Health, Vientiane, Lao People’s Democratic Republic 5. College of Pharmacy, University of Hawaii at Hilo, 60 Nowelo St., Ste. 101, Hilo, HI 96720, USA
  • Received:2008-02-29 Revised:2008-05-08 Online:2008-12-15 Published:2008-12-15
  • Contact: Hongjie Zhang;D. Doel Soejarto

Abstract: As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl3 extract from the vine of Gongronema napalense (Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activity in vitro with an IC50 value of 1.60 and 1.39 μM against the Plasmodium falciparum D6 and W2 clones, respectively.

Key words: Gongronema napalense, asclepiadaceae, steroid glycoside, gongroneside A, Plasmodium falciparum, antimalarial activity

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