The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase

›› 2009, Vol. 4 ›› Issue (1): 7-13.

The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase

收稿日期:2008-02-29 修回日期:2008-05-08 出版日期:2009-02-20 发布日期:2009-02-20

The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase

Yi-nan Chen; Liang Wang; Jie Ren; Yanqiu Liu;Song You *

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2008-02-29 Revised:2008-05-08 Online:2009-02-20 Published:2009-02-20
Contact: Song You

摘要/Abstract

Abstract: Spirostanol glycosides (SGs) are natural products that exhibit antifungal, antirheumatic and cytotoxic properties. Biotransformation studies showed that furostanol glycosides (FGs) can be transformed to SGs, a process which is catalyzed by recombinant F-26-O-β-glucosidase (F26G) in vitro. The selectivity of F26G depends on the structures of the substrates. The transformation mechanism involves the hydrolysis of glucose at C-26 and the cyclization of the F ring.

Key words: spirostanol glycosides, furostanol glycosides, biotransformation, F26G, selectivity

. The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase [J]. , 2009, 4(1): 7-13.

Yi-nan Chen;Liang Wang;Jie Ren;Yanqiu Liu;Song You * . The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase [J]. , 2009, 4(1): 7-13.

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The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase

The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase

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