亚洲传统医药
亚洲传统医药

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›› 2009, Vol. 4 ›› Issue (4): 141-146.

• 论文 • 上一篇    下一篇

Antimicrobial activity of Calophyllum inophyllum crude extracts obtained by pressurized liquid extraction

  

  • 收稿日期:2009-04-03 修回日期:2009-07-13 出版日期:2009-08-20 发布日期:2009-08-20

Antimicrobial activity of Calophyllum inophyllum crude extracts obtained by pressurized liquid extraction

Minh Hien Ha 1 *; Van Thi Nguyen 1; Khac Quynh Cu Nguyen 2;
Emily LC Cheah 3; Paul WS Heng 3
  

  1. 1. Research and Training Department, Institute of Drug Quality Control-Ho Chi Minh City, 200 CoBac Street, District 1, Ho Chi Minh City, Vietnam; 2. Faculty of Pharmacy, University of Medicine and Pharmacy of Ho Chi Minh City, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City, Vietnam; 3. Department of Pharmacy, Faculty of Science, GEA-NUS Pharmaceutical Processing Research Laboratory, National University of Singapore, Singapore 117543, Singapore
  • Received:2009-04-03 Revised:2009-07-13 Online:2009-08-20 Published:2009-08-20
  • Contact: Minh Hien Ha

Abstract: The fruit peel of Calophyllum inophyllum is considered waste material from the production of oils from its fruit and is abundantly available in Vietnam. The preparation of extracts was carried out by the pressurized liquid extraction (PLE) method. The preliminary phytochemical screening revealed the presence of phenolic compounds. The antimicrobial studies of the methanolic and n-hexane extracts were carried out on standard micro-organisms, Staphylococcus aureus (ATCC 6538 P), Mycobacterium smegmatis (ATCC 14468), and Pseudomonas aeruginosa (ATCC 9027), using the disc diffusion method. The extracts demonstrated promising antibacterial activity against Staphylococcus aureus and Mycobacterium smegmatis. The presence of phenolic compounds was likely to be responsible for these activities.

Key words: Calophyllum inophyllum, fruit peel, phenolic compound, antimicrobial activity

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