亚洲传统医药
亚洲传统医药

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›› 2011, Vol. 6 ›› Issue (5): 203-210.

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Sedative activity studies on the aqueous and alcohol extracts of the stem bark of Madanaphala - an ayurvedic drug (Catunaregam spinosa (Thunberg) Tiruvengadam)

  

  • 收稿日期:2010-11-06 修回日期:2011-08-22 出版日期:2011-10-20 发布日期:2011-10-20

Sedative activity studies on the aqueous and alcohol extracts of the stem bark of Madanaphala - an ayurvedic drug (Catunaregam spinosa (Thunberg) Tiruvengadam)

Varadharajan Madhavan 1, Bankapura Vedavathi 1, Asirvadam Raju 2, Anita Murali 2*, Sunkam Yoganarasimhan 1   

  1. 1. Department of Pharmacognosy, MS Ramaiah College of Pharmacy, Bangalore 560054, Karnataka, India 2. Department of Pharmacology, MS Ramaiah College of Pharmacy, Bangalore 560054, Karnataka, India
  • Received:2010-11-06 Revised:2011-08-22 Online:2011-10-20 Published:2011-10-20
  • Contact: Anita Murali

Abstract: Madanaphala is an important drug used in Ayurveda and Siddha formulations. The botanical source of Madanaphala is Catunaregam spinosa (Thunb.) Tiruven. In the present study, the sedative activity of C. spinosa stem bark has been evaluated by studying the effect of the plant extracts on locomotor activity using an actophotometer, and anxiolytic activity involving several models including elevated plus maze and thiopentone sodium induced sleeping time. Alcohol (EECS) and aqueous (AECS) extracts of C. spinosa at doses 200 and 400 mg/kg significantly (P<0.001) reduced the spontaneous motor activity, whereas 400 mg/kg AECS, 200 and 400 mg/kg EECS significantly (P<0.001) increased the open arm occupancy and also increased the thiopentone sodium-induced sleeping time. The results were comparable with those of the standard sedative drug diazepam. It was concluded that the stem bark of C. spinosa possesses significant sedative activity.

Key words: actophotometer, Catunaregam spinosa, sedative activity

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