1. Department of Pharmacy and Pharmacology, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal 2. Department of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan 3. Department of Biomedical Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan 4. Department of Drug Administration, Nepal Government, Kathmandu,Madan Bhandari Path-4, Nepal