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›› 2015, Vol. 10 ›› Issue (3): 69-78.

• 论文 • 上一篇    

Study on the quality control of Shang-Ke Bone-Knitting Tablet (SKBT)

Zehai Song 1, Luhui Li 1, Qiao Li 1, Na Han 1, Zhihui Liu 1, Jun Yin 1*   

  1. 1 Development and Utilization Key Laboratory of Northeast Plant Materials, School ofTraditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 WenhuaRoad , Shenyang, Liaoning, 110016, China
  • 收稿日期:2015-01-29 修回日期:2015-07-12 出版日期:2015-06-30 发布日期:2015-06-30
  • 通讯作者: Jun Yin

Study on the quality control of Shang-Ke Bone-Knitting Tablet (SKBT)

Zehai Song 1, Luhui Li 1, Qiao Li 1, Na Han 1, Zhihui Liu 1, Jun Yin 1*   

  1. 1 Development and Utilization Key Laboratory of Northeast Plant Materials, School ofTraditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 WenhuaRoad , Shenyang, Liaoning, 110016, China
  • Received:2015-01-29 Revised:2015-07-12 Online:2015-06-30 Published:2015-06-30
  • Contact: Jun Yin

摘要： Shang-ke Bone-knitting tablet (SKBT) is widely used in China because of its excellent efficiency on bone-fracture healing, which
is composed of 12 kinds of drugs. In order to improve and strengthen the quality control standards of SKBT, three drugs, Asterias
Amurensis (hai xing), Olibanum (zhi ru xiang), Myrrha (zhi mo yao), were chosen because of their contributions to the efficacy
of SKBT and were identified by thin-layer chromatography (TLC). The results showed that the TLC method we have developed
was reliable, accurate, simple and easily operated. The method was appropriate to control the quality of SKBT. Except for the
TLC part, a simple, rapid and sensitive high-performance liquid chromatography (HPLC)-UV method has been developed
to simultaneously quantify three active saponins of Notoginseng Radix et Rhizoma (notoginsenoside R1, ginsenoside Rg1 and
ginsenoside Rb1). Methodological investigation indicated that the developed HPLC assay could be readily utilized as a quality
control and quantitative analysis method of SKBT.

Abstract: Shang-ke Bone-knitting tablet (SKBT) is widely used in China because of its excellent efficiency on bone-fracture healing, which
is composed of 12 kinds of drugs. In order to improve and strengthen the quality control standards of SKBT, three drugs, Asterias
Amurensis (hai xing), Olibanum (zhi ru xiang), Myrrha (zhi mo yao), were chosen because of their contributions to the efficacy
of SKBT and were identified by thin-layer chromatography (TLC). The results showed that the TLC method we have developed
was reliable, accurate, simple and easily operated. The method was appropriate to control the quality of SKBT. Except for the
TLC part, a simple, rapid and sensitive high-performance liquid chromatography (HPLC)-UV method has been developed
to simultaneously quantify three active saponins of Notoginseng Radix et Rhizoma (notoginsenoside R1, ginsenoside Rg1 and
ginsenoside Rb1). Methodological investigation indicated that the developed HPLC assay could be readily utilized as a quality
control and quantitative analysis method of SKBT.

Key words: Shang-Ke Bone-Knitting tablet, TLC, HPLC, quality control, quantitative analysis

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