亚洲传统医药

关键词: In vitro antioxidant, antiulcer, total flavonoid content, anti-radical power

Abstract: To identify the potential lead as in vitro antioxidant and antiulcer activity from selected Indian medicinal plants. The 50% ethanolic extract (crude extract) of A. speciosa, B. prionitis, B. alba, F. indica and C. orchioides were subjected to preliminary phytochemical screening, estimation of total flavonoid content and in vitro antioxidant study like DPPH• , hydroxyl radical and nitric oxide scavenging activity. The crude extract of each plant at a dose of 400 mg/kg b.w were administered orally bis in die for the treatment of ulcer induced by chemical and physical method like aspirin and pylorus ligation induced ulcer models. The total flavonoid content and in vitro antioxidant studies gave the higher values in B. alba among the other selected plants. The crude extract of B. alba leaves gave the best antiulcer activity against A. speciosa, B. prionitis, F. indica and C. orchioides with percentage protection values of 72.4% (aspirin induced ulcer) and 67.4% (pylorus ligation induced ulcer), respectively. The 50% ethanolic extract of leaves of B. alba has higher phenolic content in comparison to the other plants extract, which clearly explains the reason for the strong and efficient in vitro antioxidant and antiulcer activity.

Key words: In vitro antioxidant, antiulcer, total flavonoid content, anti-radical power