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Abubakar Mohammed, Syed Ibrahim Rizvi
Abubakar Mohammed, Syed Ibrahim Rizvi
摘要: Mangifera indica Linn (Fam. Anacardiaceae), popularly known as the mango plant, is reported to have antioxidant and antidiabetic properties. The present study was conducted to evaluate the antioxidant and antidiabetic efficacy of the ethanolic extract of young (YLE) and matured (MLE) leaves of Mangifera indica. Methods: This research work was carried out in the month of March and April 2015. Diabetes was induced in rats using streptozotocin. The rats were randomly assigned into six groups: Group I-Normal control (NC), Group II-diabetic control (DC), Group III-diabetic+YLE, Group IV-diabetic+MLE, Group V-matured leaf extract (MLE), Group VI-young leaf extract (YLE) respectively. At the end of the experiment (28 days) blood samples were obtained by cardiac puncture and the erythrocytes and plasma obtained from the blood was used for various experiments. Results: The study proves that the extract of leaves of Mangifera Indica has the ability to positively affect the biomarkers of oxidative stress in diabetic rats. The young leaves extract showed more potential. Conclusion: The ethanolic extract of Mangifera indica has promising therapeutic prospects as an antioxidant for the management and treatment of DM.