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Sainan Meng 1?, Xia Chen 1?, Bo Yuan 2, Jincai Lu 3, Haiyan Xu 2, Xiang Zhao 4, Feng Xu 1*
Sainan Meng 1?, Xia Chen 1?, Bo Yuan 2, Jincai Lu 3, Haiyan Xu 2, Xiang Zhao 4, Feng Xu 1*
摘要: The content of ginsenosides and antioxidative activity of different ginseng extracts were investigated to explore the molecular compliance of antioxidative activity with ginsenosides in wild ginseng, transplant wild ginseng and cultivated ginseng in this research. The results of TLC and HPLC-MS showed that three different ginseng extracts contain the same kinds of ginsenosides, however, the content of ginsenoside Re is significantly different. All three kinds of ginseng extracts protected PC12 cells from H2O2-induced oxidative injury. Three kinds of ginseng extracts increased the levels of intracellular glutathione peroxidase (GSH-PX) and total-superoxide dismutase (T-SOD), decreased intracellular reactive oxygen species (ROS) generation and Malondialdehyde (MDA) production. The extract of wild ginseng exhibited strongest modulation on cell viability and GSH-PX activity, which is consistent with the difference of Re content in three ginseng extracts. The difference in antioxidant activity may be closely related to the content of ginsenoside Re in three ginseng extracts.