亚洲传统医药

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Treatment Mechanisms of Traditional Chinese Medicines for Liver Fibrosis

Ming Song, Mengyue Zhang, Xin Wu*   

  1. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China
  • 收稿日期:2017-11-21 修回日期:2017-12-29 出版日期:2017-12-20 发布日期:2017-12-29

Treatment Mechanisms of Traditional Chinese Medicines for Liver Fibrosis

Ming Song, Mengyue Zhang, Xin Wu*   

  1. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China
  • Received:2017-11-21 Revised:2017-12-29 Online:2017-12-20 Published:2017-12-29
  • Contact: Institute of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, No.103 Wenhua Road, Shenyang, 110016, China; Tel: +86-24-23986400; E-mail: wuxin44771@163. com

摘要: Liver fibrosis is a condition of abnormal proliferation of connective tissue due to various types of chronic liver injury. Evidence indicates that some traditional Chinese medicines are more effective to treat liver fibrosis clinically. In this review, the treatment mechanisms of traditional Chinese medicines for liver fibrosis are reviewed. We focus on traditional Chinese medicines against liver fibrosis in inhibition of viral replication, inhibiting hepatic stellate cell proliferation, anti-oxidation actions and regulation of cytokines. Evidence indicates that some traditional Chinese medicines are more effective to treat liver fibrosis, and the treatment mechanism of a traditional Chinese medicine for liver fibrosis may not be independent, but the combined effect. Additionally, a strict quality control of traditional Chinese medicines is critical for pharmacological, clinical and in-depth mechanism studies.

关键词: traditional Chinese medicine, liver fibrosis, hepatic stellate cells (HSCs), mechanism

Abstract: Liver fibrosis is a condition of abnormal proliferation of connective tissue due to various types of chronic liver injury. Evidence indicates that some traditional Chinese medicines are more effective to treat liver fibrosis clinically. In this review, the treatment mechanisms of traditional Chinese medicines for liver fibrosis are reviewed. We focus on traditional Chinese medicines against liver fibrosis in inhibition of viral replication, inhibiting hepatic stellate cell proliferation, anti-oxidation actions and regulation of cytokines. Evidence indicates that some traditional Chinese medicines are more effective to treat liver fibrosis, and the treatment mechanism of a traditional Chinese medicine for liver fibrosis may not be independent, but the combined effect. Additionally, a strict quality control of traditional Chinese medicines is critical for pharmacological, clinical and in-depth mechanism studies.

Key words: traditional Chinese medicine, liver fibrosis, hepatic stellate cells (HSCs), mechanism