Tyrosinase inhibitory compounds from safflower

亚洲传统医药

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Tyrosinase inhibitory compounds from safflower

Zhiyang Yan, Peng Zhao, Xiaoxiao Huang*

Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China;

收稿日期:2017-08-21 修回日期:2017-09-28 出版日期:2017-12-20 发布日期:2017-09-28

Tyrosinase inhibitory compounds from safflower

Zhiyang Yan, Peng Zhao, Xiaoxiao Huang*

Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China;

Received:2017-08-21 Revised:2017-09-28 Online:2017-12-20 Published:2017-09-28
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986486 (Xiaoxiao Huang); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang).

摘要/Abstract

摘要： Long term investigation on chemical constituents of safflower result in the isolation of 11 compounds from its water extractive. Their structures were determined by comprehensive spectroscopic data analyses. To evaluate their effect on melanogenesis, the obtained substances were evaluated for their inhibitory activity against tyrosinase and compounds 2, 4 and 7 exhibited outstanding inhibition, with inhibitory ratios at 91.3%, 87.1% and 95.0% at 100 mM, compared to the positive control arbutin (54.3%). The combination modes between compounds and tyrosinase were reasonably deduced by molecular docking.

关键词: safflower, tyrosinase inhibition, docking study

Abstract: Long term investigation on chemical constituents of safflower result in the isolation of 11 compounds from its water extractive. Their structures were determined by comprehensive spectroscopic data analyses. To evaluate their effect on melanogenesis, the obtained substances were evaluated for their inhibitory activity against tyrosinase and compounds 2, 4 and 7 exhibited outstanding inhibition, with inhibitory ratios at 91.3%, 87.1% and 95.0% at 100 mM, compared to the positive control arbutin (54.3%). The combination modes between compounds and tyrosinase were reasonably deduced by molecular docking.

Key words: safflower, tyrosinase inhibition, docking study

Zhiyang Yan, Peng Zhao, Xiaoxiao Huang. Tyrosinase inhibitory compounds from safflower[J]. 亚洲传统医药.

Zhiyang Yan, Peng Zhao, Xiaoxiao Huang. Tyrosinase inhibitory compounds from safflower[J]. Asina Journal Of Traditional Medicines.

[1]	Han Zhang, Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang. Phenolic compounds from Pithecellobium clypearia with tyrosinase inhibitory activity[J]. 亚洲传统医药, 2018, 13(2): 77-83.
[2]	Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang. Studies on the chemical constituents of Safflower (Carthamus tinctorius L.) and their tyrosinase inhibitory activity[J]. 亚洲传统医药, 2017, 12(3): 128-135.

亚洲传统医药

Tyrosinase inhibitory compounds from safflower

Tyrosinase inhibitory compounds from safflower

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