Network pharmacology-based screening of the active
ingredients and potential targets of the genus of
Croton for application to lung cancer

亚洲传统医药 ›› 2019, Vol. 14 ›› Issue (5): 219-226.

• Regular Article • 下一篇

Network pharmacology-based screening of the active ingredients and potential targets of the genus of Croton for application to lung cancer

Shaochun Shi, Yeqing Du, Chunxin Zou, Qingbo Liu*, Shaojiang Song*

Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China

收稿日期:2018-11-24 接受日期:2019-03-08 出版日期:2019-10-20 发布日期:2019-12-09

Network pharmacology-based screening of the active ingredients and potential targets of the genus of Croton for application to lung cancer

Shaochun Shi, Yeqing Du, Chunxin Zou, Qingbo Liu*, Shaojiang Song*

Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China

Received:2018-11-24 Accepted:2019-03-08 Online:2019-10-20 Published:2019-12-09
Contact: Address: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986486 (Qingbo Liu); +86-24-23986510 (Shaojiang Song); E-mail: liuqingbolily@126.com (Qingbo Liu); songsj99@163.com (Shaojiang Song) E-mail:liuqingbolily@126.com; songsj99@163.com

摘要/Abstract

摘要： Lung cancer has been the most common cancer in the world for several decades, and it was also the most common cause of death from cancer. Despite the several advances in the last few years into treatment of lung cancer, the survival remains extremely low. There is an urgent need to discover viable leads that can be developed into new clinically therapeutic drugs with good treatment effects. The analysis of current reported literatures suggest that natural products possess strong inhibitory efficacy against lung cancer. The plants of Croton genus belonging to Euphorbiaceae family, are widely used as herbal medicine in the folk. Which are reported to have abilities to treat several cancer cell lines especially lung cancer, a successive study was carried out to identify selective anticancer agents from these plants specie. Herein we employed a network pharmacological approach to understand its multi-therapeutics potentiality in Croton genus against lung cancer. In total, the database of the compound was established based on the methods of network pharmacology prediction and the compound-disease target network was constructed. We believed that our study would provide important clues for finding novel drug inhibitors for lung cancer.

关键词: lung cancer, Croton genus, network pharmacology

Abstract: Lung cancer has been the most common cancer in the world for several decades, and it was also the most common cause of death from cancer. Despite the several advances in the last few years into treatment of lung cancer, the survival remains extremely low. There is an urgent need to discover viable leads that can be developed into new clinically therapeutic drugs with good treatment effects. The analysis of current reported literatures suggest that natural products possess strong inhibitory efficacy against lung cancer. The plants of Croton genus belonging to Euphorbiaceae family, are widely used as herbal medicine in the folk. Which are reported to have abilities to treat several cancer cell lines especially lung cancer, a successive study was carried out to identify selective anticancer agents from these plants specie. Herein we employed a network pharmacological approach to understand its multi-therapeutics potentiality in Croton genus against lung cancer. In total, the database of the compound was established based on the methods of network pharmacology prediction and the compound-disease target network was constructed. We believed that our study would provide important clues for finding novel drug inhibitors for lung cancer.

Key words: lung cancer, Croton genus, network pharmacology

Shaochun Shi, Yeqing Du, Chunxin Zou, Qingbo Liu, Shaojiang Song. Network pharmacology-based screening of the active ingredients and potential targets of the genus of Croton for application to lung cancer[J]. 亚洲传统医药, 2019, 14(5): 219-226.

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Network pharmacology-based screening of the active ingredients and potential targets of the genus of Croton for application to lung cancer

Network pharmacology-based screening of the active ingredients and potential targets of the genus of Croton for application to lung cancer

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