亚洲传统医药 ›› 2019, Vol. 14 ›› Issue (6): 260-267.

• Regular Article • 上一篇    下一篇

Virtual screening of active ingredients, potential targets and pathways from Elephantopus scaber L. against liver cancer based on network pharmacology

Shuhui Dong, Ming Bai, Xiaoxiao Huang*, Shaojiang Song*   

  1. Department of Natural Products Chemistry, Key Laboratory of Computational ChemistryBased Natural Antitumor drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China
  • 收稿日期:2019-01-11 接受日期:2019-05-18 出版日期:2019-12-20 发布日期:2020-01-02

Virtual screening of active ingredients, potential targets and pathways from Elephantopus scaber L. against liver cancer based on network pharmacology

Shuhui Dong, Ming Bai, Xiaoxiao Huang*, Shaojiang Song*   

  1. Department of Natural Products Chemistry, Key Laboratory of Computational ChemistryBased Natural Antitumor drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China
  • Received:2019-01-11 Accepted:2019-05-18 Online:2019-12-20 Published:2020-01-02
  • Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986510 (Xiaoxiao Huang); +86-24-23986510 (Shaojiang Song); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang); songsj99@163.com (Shaojiang Song) E-mail:xiaoxiao270@163.com;songsj99@163.com

摘要: Elephantopus scaber L., belonging to Elephantopus plant of Compositae, is widely used as the common Chinese herbal medicine in folk. According to the phytochemical investigations, E. scaber is used to treat several cancers, anemia and diarrhea on account of the property of the complex components and multi-targets. However, the underlying molecular mechanisms of herb remain unclear. In this report, network pharmacology method is used to analyze the relation among the small-molecule compounds of E. scaber, target proteins, biological pathways and liver cancer. The potential active compounds from the E. scaber, potential target proteins and the key pathways were predicted by network pharmacology models. We believe that our present study is useful to find novel lead compounds for liver cancer.

关键词: Elephantopus scaber L., network pharmacology, liver cancer

Abstract: Elephantopus scaber L., belonging to Elephantopus plant of Compositae, is widely used as the common Chinese herbal medicine in folk. According to the phytochemical investigations, E. scaber is used to treat several cancers, anemia and diarrhea on account of the property of the complex components and multi-targets. However, the underlying molecular mechanisms of herb remain unclear. In this report, network pharmacology method is used to analyze the relation among the small-molecule compounds of E. scaber, target proteins, biological pathways and liver cancer. The potential active compounds from the E. scaber, potential target proteins and the key pathways were predicted by network pharmacology models. We believe that our present study is useful to find novel lead compounds for liver cancer.

Key words: Elephantopus scaber L., network pharmacology, liver cancer