亚洲传统医药
亚洲传统医药

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亚洲传统医药 ›› 2020, Vol. 15 ›› Issue (5): 228-238.

• Regular Article • 上一篇    下一篇

Bioactive Constituents of the Seed Kernels from Vernicia fordii

Jiayi Li, Jing Ding, Zisong Bai, Gang Chen, Di Zhou*, Ning Li*   

  1. School of Traditional Chinese Materia Medica; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 收稿日期:2020-03-16 修回日期:2020-06-30 接受日期:2020-06-30 出版日期:2020-10-20 发布日期:2020-10-30

Bioactive Constituents of the Seed Kernels from Vernicia fordii

Jiayi Li, Jing Ding, Zisong Bai, Gang Chen, Di Zhou*, Ning Li*   

  1. School of Traditional Chinese Materia Medica; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug, Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received:2020-03-16 Revised:2020-06-30 Accepted:2020-06-30 Online:2020-10-20 Published:2020-10-30
  • Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Tel.: +86-24-43520739, Fax: +86-24-31509368; E-mail: liningsypharm@163.com. E-mail:liningsypharm@163.com

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摘要： A new compound, (2′R)-(5-oxo-2,5-dihydrofuran-2-yl)methyl octanoate (1), together with 9 known ones (2-10) were isolated from the bioactive extract of the seed kernels from Vernicia fordii. Their structures were determined by spectroscopic analyses, including Nuclear Magnetic Resonance (NMR) and High Resolution Electrospray Ionization Mass Spectroscopy (HRESI-MS). Their cytotoxicities against three human cancer cell lines (A549, HepG2 and Caco2 cells) and anti-neuroinflammatory effects were evaluated. Cytotoxicity assay revealed that compound 9 could inhibit the growth of HepG2 cells, while compound 6 had a moderate inhibitory effect against A549 cells. Further anti-neuroinflammatory activity assay showed that compound 10 exhibited moderate inhibitory effect on the release of NO in LPS-stimulated BV2 microglia cells.

关键词: Vernicia fordii, active component, cytotoxicity, anti-neuroinflammatory activity

Abstract: A new compound, (2′R)-(5-oxo-2,5-dihydrofuran-2-yl)methyl octanoate (1), together with 9 known ones (2-10) were isolated from the bioactive extract of the seed kernels from Vernicia fordii. Their structures were determined by spectroscopic analyses, including Nuclear Magnetic Resonance (NMR) and High Resolution Electrospray Ionization Mass Spectroscopy (HRESI-MS). Their cytotoxicities against three human cancer cell lines (A549, HepG2 and Caco2 cells) and anti-neuroinflammatory effects were evaluated. Cytotoxicity assay revealed that compound 9 could inhibit the growth of HepG2 cells, while compound 6 had a moderate inhibitory effect against A549 cells. Further anti-neuroinflammatory activity assay showed that compound 10 exhibited moderate inhibitory effect on the release of NO in LPS-stimulated BV2 microglia cells.

Key words: Vernicia fordii, active component, cytotoxicity, anti-neuroinflammatory activity

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