Network pharmacology-based study on compounds from
Camptotheca acuminate inhibiting liver cancer cells

亚洲传统医药 ›› 2021, Vol. 16 ›› Issue (1): 1-9.

• Regular Article • 下一篇

Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells

Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang*, Shaojiang Song*

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

收稿日期:2020-04-22 接受日期:2020-06-01 出版日期:2021-02-20 发布日期:2021-03-02

Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells

Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang*, Shaojiang Song*

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2020-04-22 Accepted:2020-06-01 Online:2021-02-20 Published:2021-03-02
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-43520793 (Xiaoxiao Huang), +86-24-43520707 (Shaojiang Song); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang), songsj99@163.com (Shaojiang Song). E-mail:xiaoxiao270@163.com;songsj99@163.com

摘要/Abstract

摘要： Camptotheca acuminate belongs to Nyssaceae family and has been used as traditional Chinese medicine for several years. A number of compounds with anti-tumor activities have been isolated from C. acuminate. However, the targets of some compounds have not been determined. In this study, network pharmacology methods were used to analyze 74 compounds from C. acuminate and 49 target proteins of liver cancer. The results showed that the target with the largest number of directed edges was Dihydroorotate Dehydrogenase (1d3g). The compound docked with 1d3g best was AL.23 (19-O-methyangustoline). The results of this study provide further insight into the role of network pharmacology as an effective tool to illuminate the research on liver cancer.

关键词: Camptotheca acuminate, liver cancer, network pharmacology

Abstract: Camptotheca acuminate belongs to Nyssaceae family and has been used as traditional Chinese medicine for several years. A number of compounds with anti-tumor activities have been isolated from C. acuminate. However, the targets of some compounds have not been determined. In this study, network pharmacology methods were used to analyze 74 compounds from C. acuminate and 49 target proteins of liver cancer. The results showed that the target with the largest number of directed edges was Dihydroorotate Dehydrogenase (1d3g). The compound docked with 1d3g best was AL.23 (19-O-methyangustoline). The results of this study provide further insight into the role of network pharmacology as an effective tool to illuminate the research on liver cancer.

Key words: Camptotheca acuminate, liver cancer, network pharmacology

Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang, Shaojiang Song. Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells[J]. 亚洲传统医药, 2021, 16(1): 1-9.

Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang, Shaojiang Song. Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells[J]. Asian Journal of Traditional Medicines, 2021, 16(1): 1-9.

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Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells

Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells

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