亚洲传统医药
亚洲传统医药

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›› 2007, Vol. 2 ›› Issue (6): 212-217.

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A new methodology that improves the neuroprotective properties of the traditional Chinese medicine prescription, NaoDeSheng

  

  • 收稿日期:2007-01-01 修回日期:2007-01-01 出版日期:2007-12-15 发布日期:2007-12-15

A new methodology that improves the neuroprotective properties of the traditional Chinese medicine prescription, NaoDeSheng

Li Zhang 1; Xinrui Cheng 2#; Guanhua Du 1*
  

  1. 1. National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China 2. Department of Pharmacology, Institute of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, China
  • Received:2007-01-01 Revised:2007-01-01 Online:2007-12-15 Published:2007-12-15
  • Contact: Guanhua Du

Abstract: Neuro-protective effects of components of the traditional Chinese medicine prescription, NaoDeSheng, and their mechanism(s) of action were investigated. The effects of 170 samples isolated from NaoDeSheng were studied in an ischemia-related PC12 nerve cell injury model, The effects on several toxic effects were determined, including glutamate-induced excitoxicity, hydrogen peroxide-induced cytotoxicity, N-methyl-D-aspartic acid (NMDA)-induced neurotoxicity, and mitochondrial injury. Some of these samples reduce the levels of nitric oxide (NO) and lactic acid dehydrogenase in the supernatant fluid fraction of PC12 cells and increase cell viability. Therefore, the use of a combination of effective components of NaoDeSheng may be useful in reducing deleterious effects of cerebral ischemia. The results reported here suggest that the methods used may lead to improvements in the use and preparation of the traditional Chinese medicine prescription, NaoDeSheng .

Key words: traditional Chinese medicine, NaoDeSheng, High-throughput screening, effective composite.

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