Asian Journal
Of Traditional Medicines

Abstract: Strychni Semen has anti-tumor, analgesia, anti-inflammatory and anti-angiogenesis effects, but the clinical use of Strychni Semen is limited by its narrow therapeutic dose. The neurotoxicity caused by Strychni Semen and its major toxic constituents, strychnine and brucine, was reported in many clinical cases. The serious neurotoxicity effects caused by Strychni Semen lead to various symptoms. Its toxic components could pass through blood-brain barrier which might cause neuro-structural, neurofunctional, and neuro-behavioral changes. In this review, the potential neurotoxicity mechanisms and compatibility attenuation are summarized by searching a lot of literatures from 1962 to 2017 which not only providing the basis to future studies of herb medicines toxicity, but also reasonable proposes to clinical application of compatibility and detoxicity on Strychni Semen.

Key words: Strychni Semen, neurotoxicity, compatibility, detoxicity