Anti-diabetic efficacy of young and mature leaf
extract of Mangifera indica

Anti-diabetic efficacy of young and mature leaf extract of Mangifera indica

Abubakar Mohammed, Syed Ibrahim Rizvi

Department of Biochemistry, University of Allahabad, Allahabad U. P. 211002, India. P. 211002, India

Received:2016-03-18 Revised:2016-10-21 Online:2017-02-20 Published:2016-10-21
Contact: Syed Ibrahim Rizvi, Department of Biochemistry, University of Allahabad, Allahabad U. P. 211 002, India; Tel.: +919415305910; E-mail: sirizvi@gmail.com.

Abstract

Abstract: Mangifera indica Linn (Fam. Anacardiaceae), popularly known as the mango plant, is reported to have antioxidant and antidiabetic properties. The present study was conducted to evaluate the antioxidant and antidiabetic efficacy of the ethanolic extract of young (YLE) and matured (MLE) leaves of Mangifera indica. Methods: This research work was carried out in the month of March and April 2015. Diabetes was induced in rats using streptozotocin. The rats were randomly assigned into six groups: Group I-Normal control (NC), Group II-diabetic control (DC), Group III-diabetic+YLE, Group IV-diabetic+MLE, Group V-matured leaf extract (MLE), Group VI-young leaf extract (YLE) respectively. At the end of the experiment (28 days) blood samples were obtained by cardiac puncture and the erythrocytes and plasma obtained from the blood was used for various experiments. Results: The study proves that the extract of leaves of Mangifera Indica has the ability to positively affect the biomarkers of oxidative stress in diabetic rats. The young leaves extract showed more potential. Conclusion: The ethanolic extract of Mangifera indica has promising therapeutic prospects as an antioxidant for the management and treatment of DM.

Key words: Mangifera Indica, diabetes, free radicals, natural products, phytochemicals

Abubakar Mohammed, Syed Ibrahim Rizvi. Anti-diabetic efficacy of young and mature leaf extract of Mangifera indica[J]. Asina Journal Of Traditional Medicines.

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