Asian Journal
Of Traditional Medicines

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Please wait a minute... For Selected: Download Citations EndNote Reference Manager ProCite BibTeX RefWorks Toggle Thumbnails Select The Protective Effect of Ginsenoside Re against Cerebral Ischemia Xiaomian Zhou;Yu Zou;Yinglin Cao;Yaming Cao* null    2006, 1 (3-4): 112-116.   Abstract （2607）            Knowledge map    To observe the protective effect of ginsenoside Re against cerebral ischemia, mice were subjected to bilateral carotid artery and cranial nerve ligation, and the cerebral index, the cerebral water content , the activities of cerebral SOD and the content of cerebral MDA were determined at the same time. Hypoglucose and hypoxia injury models were used to determine the protective effect of ginsenoside Re on PC12 cells. Following pretreatment with ginsenoside Re ( 8，16，32 mg·kg-1 ) for 10 days in mice, the cerebral index, the cerebral water content and cerebral MDA content were significantly reduced, and the activity of cerebral SOD was improved compared with the controls; the cell survival rate was significantly improved and the LDH activity was markedly reduced with ginsenoside Re(10-8，10-7，10-6，10-5 mol·L-1 ) for 18 h in PC12 cells. Related Articles | Metrics Cited: Baidu(68) Select Antidiabetic activities of methanol-derived extract of Dorstenia picta twigs in normal and streptozotocin-induced diabetic rats Ngueguim Tsofack Florence;Dimo Théophile *;Dzeufiet Djomeni Paul Désiré;Vouffo Bertin;Dongo Etienne;Renaud Beauwens;Asongalem Acha Emmanuel;Zapfack Louis;Kamtchouing Pierre null    2007, 2 (4): 140-148.   Abstract （2773）            Knowledge map    We investigated the effect of Dorstenia picta methanolic residue extract on blood glucose levels and some biochemical parameters in normal and streptozotocin-induced diabetic rats. Single oral administration of the extract at a dose of 75 mg/kg, significantly, reduced the blood glucose levels by 23.74 % and 29.79 %, in normal and diabetic rats, respectively after 5 hours. In glucose tolerance test (OGTT), the extract (75 mg/kg) produced a significant blood glucose lowering effect. Repeated doses of distilled water, insulin, 75 and 150 mg/kg of extract were administered orally and once daily to normal and streptozotocin-induced diabetic rats for 14 consecutive days. D. picta and insulin prevented body weight lost, polyphagia and polydipsia, as well as a significant (p <0.01) decreased in blood glucose at the dose of 75 mg/kg (53.88 %) and 150 mg/kg (81.96 %). There was also significant decrease of elevated serum cholesterol and triglycerides in both normal and diabetic rats. At these doses, reductions of plasma alanine and aspartate transaminase levels were recorded in both normal and diabetic rats but creatinine and total protein remained unchanged. These data indicated that D. picta treatment may improve glucose homeostasis in streptozotocin-induced diabetes which could be linked to insulin-like activity and ameliorate kidney and liver functions. D. picta twigs have antidiabetic effect and could be a potential source of new oral antidiabetic drug. Related Articles | Metrics Cited: Baidu(22) Select A molecular Biological Method for Screening and Evaluating the Traditional Chinese Medicine Used in Pi-deficiency Therapy Involving Intestinal microflora Jing Kong;Xiaobo Li＊;and Chunfu Wu null    2006, 1 (1): 1-6.   Abstract （2804）            Knowledge map    Pi-deficiency (“Spleen” deficiency), a common syndrome seen in clinics practising Traditional Chinese Medicine (TCM), is one of the main digestive system diseases and is associated with gastrointestinal microflora. In this study, a molecular biology method of evaluating and screening Pi-deficiency therapy and other TCM related to intestinal microflora was established. The intestinal microflora were isolated from mice feces for analysis; the total DNA extracted from the fecal intestinal microflora and its Enterobacterial Repetitive Intergenic Consensus PCR (ERIC-PCR) protocol were studied. The Pi-deficiency model involved treatment with an aqueous extract of Radix et Rhizoma Rhei and Reserpine. An analysis and comparison of the ERIC-PCR fingerprints of intestinal microflora of mice feces obtained from healthy animals, Pi-deficient animals and those cured by decoctions of Si-jun-zi-tang and Li-zhong-tang were carried out . The ERIC-PCR fingerprints showed changes in all the intestinal microflora, and the method was found to be an efficient method for evaluating and screening Pi-deficiency therapy and the other TCM acting on intestinal microflora. Related Articles | Metrics Cited: Baidu(16) Select A new flavonoid glycoside from the seeds of Fagopyrum tataricum Yaqing Wu;Bohang Sun;Jian Huang;Huiyuan Gao;Lijun Wu* null    2007, 2 (5): 202-205.   Abstract （1450）            Knowledge map    A new flavonoid glycoside, characterized as quercetin 3-O-rutinoside-3′-O-β-glucopyranoside (1), has been isolated from the seeds of Fagopyrum tataricum by chromatographic methods. Detailed HMQC and HMBC have been provided for the new compound. Related Articles | Metrics Cited: Baidu(13) Select HPLC determination of two bioactive flavone glycosides and GC-MS analysis of volatile oil constituents in Alpinia nigra Chunfeng Qiao;Quanbin Han;Jingzheng Song;Zhengtao Wang *;Luoshan Xu; Hongxi Xu * null    2007, 2 (3): 85-91.   Abstract （1799）            Knowledge map    Two bioactive flavone glycosides, astragalin and kaempferol-3-O-glucuronide, were analyzed in Alpinia nigra (Gaertn.) Burtt by HPLC. The method was validated in detail. Kaempferol-3-O-glucuronide was found to be a dominant compound in the seed clusters. It is primarily distributed in the pulp. In addition, volatile oils of fruits and rhizomes of A. nigra were studied by GC-MS. β-Pinene and α-pinene were found to be major constituents of the volatile oil of the fruits. Related Articles | Metrics Cited: Baidu(10) Select Analysis of the fatty acids from Periploca sepium by GC-MS and GC-FID Ling Tong;Lei Zhang;Shuanghui Yu;Xiaohui Chen;Kaishun Bi * null    2007, 2 (3): 110-114.   Abstract （1444）            Knowledge map    A simple and rapid gas chromatographic (GC) method with flame ionization detection was developed for the analysis of fatty oil in Periploca sepium. After methyl-esterification, nine components were identified by GC-MS. The derivatization conditions were investigated in order to validate this method. Palmitic acid, oleic acid and linoleic acid were determined simultaneously. The calibration curves were linear in the range of 0.050–0.250 mg·mL-1 for palmitic acid, 0.019–0.190 mg·mL-1 for oleic acid and 0.087–1.044 mg·mL-1 for linoleic acid, respectively. The average recovery of palmitic acid was 99.2 % (RSD = 3.3 %); oleic acid, 99.4 % (RSD = 2.6 %); linoleic acid, 100.2 % (RSD = 2.9 %). The method can be used for the analysis of the fatty acids from Periploca sepium. Related Articles | Metrics Cited: Baidu(9) Select A new cassane diterpene from Caesalpinia bonduc (fabaceae) Zhaohua Wu;Yongyi Wang;Jian Huang;Bohang Sun;Lijun Wu * null    2007, 2 (4): 135-139.   Abstract （1485）            Knowledge map    A new cassane diterpene, neocaesalpin W (1), along with a known triterpene, β-amyrin (2) was isolated from the seeds of Caesalpinia bonduc (fabaceae). The structure and relative stereochemistry of (1) was determined by spectral methods (1H NMR, 13C NMR, H-HCOSY, HMBC, HMQC and NOESY experiments. ESI-MS, IR). Compound (2) was isolated from this genus for the first time. Related Articles | Metrics Cited: Baidu(9) Select Simultaneous Determination of Five Bioactive Flavonoids in Hypericum japonicum Thunb by High-performance Liquid Chromatography Juan Li;Bo Jiang;Xiao Liu;Juan Zhang;Xiaohui Chen;Kaishun Bi * null    2007, 2 (2): 75-81.   Abstract （626）            Knowledge map    A simple reversed-phase liquid chromatographic method has been established for the simultaneous quantification of five bioactive flavonoids, i.e., taxifolin-7-O-rhamnoside, isoquercitrin, quercitrin, quercetin and kaempferol in Hypericum japonicum Thunb. Chromatographic separations were achieved on a Luna C18 column (250 mm×4.6 mm, 5 µm) with a gradient of methanol and 0.5 % aqueous acetic acid (v/v) as mobile phase and UV detection at 350 nm. The assay was reproducible with overall intra- and inter-day variation of less than 4.8 %. The mean recovery of the method was 99.8 % ± 2.5 %. Using the optimized method, 19 samples were analyzed. The results indicated that the developed HPLC assay could be readily utilized as a quality control method for Hypericum japonicum Thunb. Related Articles | Metrics Cited: Baidu(8) Select Advances in research on polysaccharides from Fructus Corni Gang Cao;Yu Zhang;Xiaodong Cong;Hao Cai;Baochang Cai;* null    2009, 4 (5): 205-209.   Abstract （1109）            Knowledge map    The polysaccharides of Fructus Corni, one of the main functional components of Fructus Corni, exhibit a variety of pharmacological and physiological activities, such as immune regulation, antioxidation, and antiaging effects, and studies on these polysaccharides have become an important topic of research in recent years. The extraction, purification, and structural analysis of Fructus Corni as well as its bioactivity are reviewed, and the effect of different processing methods on Fructus Corni is also discussed. Finally, the problems associated with current research on Fructus Corni are summarized, and the prospects for future research and development are highlighted. Related Articles | Metrics Cited: Baidu(8) Select In vitro screening of the cytotoxic, antibacterial and antioxidant activities of some Uzbek plants used in folk medicine Sobirdjan A. Sasmakov *;Zhanna M. Putieva;Shakhnoz S. Azimova;Ulrike Lindequist null    2012, 7 (2): 73-80.   Abstract （1012）            Knowledge map    The present work evaluated the antitumor, antibacterial and antioxidant activity of extracts from 24 plants used in Uzbek traditional medicine. The chloroformic extracts of Ecballium elaterium, Conium maculatum, Dodartia orientalis, Peganum harmala, Salvia sclarea, Tragopogon malicus and Vaccaria segetalis exhibited strong cytotoxicity with IC50 values ranging between 3.94 and 19.5 µg/ml. The methanolic extracts of Coronaria coriacea, Ligularia macrophylla, Otostegia bucharica, Phlomis bucharica, Salvia aethiopis, S. sclarea, Vaccaria segetalis and Zygophyllum gontscharovii showed remarkable antibacterial activity against both Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, and only the extract from Acanthophyllum albidum showed potent antifungal activity against Candida maltosa. The methanolic extracts of 7 plant species showed effective free radical scavenging in the DPPH assay. Related Articles | Metrics Cited: Baidu(7) Select A Novel Approach to the Digitized Fingerprint of Radix Bupleuriby HPLC Guoxiang Sun*;Jindan Liu;Yumeng Bi;Kaishun Bi;Yuqing Sun null    2006, 1 (3-4): 142-149.   Abstract （2561）            Knowledge map    High performance liquid chromatography was applied to the determination of the fingerprints of Radix Bupleuri. All the samples were analyzed by using a gradient elution with 1 % acetic acid in water/acetonitrile and with 1% acetic acid ( from 0 /100 to 50 /50, v /v, in 70 min ) as the mobile phase, a CenturySIL C18 AQ column ( 20 cm × 4.6 mm, 5 μm ) with the temperature of 30 ± 0.15 °C and a detection wavelength of 265 nm. The HPLC profiles produced from chromatograms of ten different batches of samples were established as characteristic fingerprints having 27 common peaks. The ten chromatograms were assessed by the software of the Digitized Evaluation System for Superinformation Characteristics of theTraditional Chinese Medicine Fingerprints chiefly in terms of similarities of the chemical constituent distribution and content. And the results showed a good similarity between the sample and the referential HPLC fingerprints. This method can exploit the potential information hidden in the HPLC fingerprints with high precision and reproducibility and serve as a perfect way of the quality control of Radix Bupleuri. Related Articles | Metrics Cited: Baidu(7) Select Plant natural products and drugs: a comprehensive study Mudasir A. Tantry * null    2009, 4 (6): 241-249.   Abstract （1366）            Knowledge map    A number of medicinal plants have been subjected to detailed chemical investigations and this has led to the isolation of pure bioactive molecules which have been pharmacologically evaluated. As a result, new drugs have been discovered, along with new applications. These bioactive molecules are used as therapeutic agents, novel starting materials and new reagents for molecular biology research. At present, there are 125 clinically useful drugs of known constitution, which have been isolated from about 100 species of higher plants. It has been estimated that about 5000 plant species have been studied in detail as possible sources of new drugs. The production of plant-based drugs in bulk is now an important challenge for the pharmaceutical industry. Related Articles | Metrics Cited: Baidu(7) Select The Quality Control of the Effective Fraction from Dioscorea spongiosa Yong Wang;Yang Liu;Zhihui Liu and Jun Yin * null    2007, 2 (1): 12-18.   Abstract （1810）            Knowledge map    It is of great importance to establish systematic quality control methods for the effective fractions of herbal medicines as part of the modernization programme for Traditional Chinese Medicines. The effective fraction from Dioscorea spongiosa and its major active component, methyl protodioscin, have been reported to have antiosteoporotic activity. In the present study, the quantitative analyses of the total saponins and methyl protodioscin of the effective fraction from Dioscorea spongiosa were established by vanillin-perchloric acid colorimetry and HPLC, respectively. The content of total saponins in three batches of effective fractions, determined by colorimetry with methyl protodioscin as the reference substance in this study, was more than 55%. The established HPLC method, which has good linearity, precision, and reproducibility as well as being highly stable and sensitive, is practical and reliable for the quality control of Dioscorea spongiosa. The combination of both methods may be also helpful for the effective fractions of other species of Dioscorea in terms of their systematic evaluation and quality control. Related Articles | Metrics Cited: Baidu(7) Select Maillard reaction contributing to chemical changes during the processing of Shu Dihuang, the steamed root of Rehmannia glutinosa Yanxia Guo;Xuesen Wen *;Yu Zhao;Guodong Wei;Ping Sun null    2012, 7 (2): 50-58.   Abstract （930）            Knowledge map    The dried root of Rehmannia glutinosa (Scrophulariaceae), Sheng Dihuang, is a well-known cooling crude drug. After a long period of steaming, it is converted to another form, Shu Dihuang, an antianemic drug. Until now, there has been little information about the chemical basis of this functional transformation. In this work, slices of Sheng Dihuang were steamed for different times (0-60 h). The absorbance at 420 nm of a sample of the aqueous extract increased more than 16 times, while the pH value had decreased from 5.4 to 3.8 by the end of the experiment. The processing was divided into two stages: the early stage (0-12 h) and the later stage (12-60 h). In the early stage, amino acids fell by more than 70%, catalpol, sucrose, raffinose and stachyose decomposed, while 5-hydroxymethyl furfural (HMF), glucose, fructose and manninotriose increased. In the later stage, however, amino acids remained at a low level, while HMF and A420 increased linearly. These drastic chemical changes were directly or indirectly related to the Maillard reaction which took place during the preparation of Shu Dihuang. Related Articles | Metrics Cited: Baidu(6) Select Anti-tumor Activity of the Compound Recipe Radix Sophorae Flavescentis for Injection in vivo and in vitro Honghao Zheng;Xiaomian Zhou *;Enlong Ma;Yinglin Cao and Yi Dai null    2007, 2 (1): 19-22.   Abstract （1575）            Knowledge map    The purpose of these experiments is to investigate the anti-tumor effect of the compound recipe Radix Sophorae Flavescentis for injection (CRS) in vitro and in vivo. The S180 , H22 , Lewis lung tumor models were established in mice and the inhibition rate of tumor growth was calculated by weighing the tumor after CRS treatment. MTT assay was used to examine its effect on HeLa and HepG-2 cells. CRS (dose: 1.6, 3.2, 6.4 g·mL-1) produced a clear inhibitory effect on the growth of S180, H22, Lewis in tumor-bearing mice, and the inhibition rate was more than 35 % (P < 0.01 vs. control group). The CRS, at a dose of 1-0.25 g·mL-1, significantly inhibited the growth of HeLa and HepG-2 cells in a dose-dependent manner. Following these results, it appears that CRS has marked inhibitory effects on tumor growth in vitro and in vivo. Related Articles | Metrics Cited: Baidu(6) Select Anti-proliferative effects of Pouzolzia indica on acute promyelocytic cell lines: NB4 and HT93A Yaowalak U-pratya;Weena Jiratchariyakul;Tanawan Kummalue * null    2008, 3 (4): 124-133.   Abstract （3177）            Knowledge map    Pouzolzia indica Gaudich. var. angustifolia Wedd., a Thai medicinal plant in the Urticaceae family, has long been used as one of the components in Thai herbal remedies for treating various malignant diseases. The antiproliferative activity of extracts obtained from this plant on acute promyelocytic cell lines, NB4 and HT93A, was investigated. It was found that a methanol fraction of the stems and leaves of this plant inhibited cell proliferation of NB4 and HT93A cells with IC50 values of 28.5 ± 0.1 and 49.8 ± 0.7 µg/ml respectively. NB4 cells (3.2 % to 22.22 %) treated with 75 µg/ml of this fraction for 24 hr underwent apoptosis compared with untreated cells whereas HT93A cells (3.02 % to 51.34 %) treated with 150 µg/ml of this fraction underwent apoptosis compared with the control cells. These results suggest that elucidation of the active chemicals in this herb will be valuable. Related Articles | Metrics Cited: Baidu(6) Select Traditional Medicines Used in Differentiation Therapy of Myeloid Leukemia Rui Wang;Dandan Song;and Yongkui Jing* null    2006, 1 (1): 37-44.   Abstract （2818）            Knowledge map    Differentiation therapy has been successfully carried out in acute promyelocytic leukemia patients with treatments involving all-trans retinoic acid, a natural metabolite of vitamin A, and arsenic trioxide, a traditional medicine. Using human myeloid leukemia cell lines, many natural products isolated from traditional herb medicines have been found to have differentiation-induction ability. Compounds from traditional medicine with cell differentiation effects in leukemia cells are described in this communication. Related Articles | Metrics Cited: Baidu(5) Select Gender differences in the bioavailability and pharmacokinetics of γ-schisandrin from a Wurenchun-PVP k30 solid dispersion in rats Tie Zhao;Mingfeng Qiu *;Guoxiang Xie;Hongbing Wu;Wei Jia null    2010, 5 (6): 203-211.   Abstract （1239）            Knowledge map    γ-Schisandrin, as one of main active components in Wurenchun, has a very low solubility in water and requires large doses to be effective. The aim of this study was to evaluate the pharmacokinetics and bioavailability of γ-schisandrin from a Wurenchun-PVP k30 solid dispersion (WSD) and conventional self-prepared capsules (CSP). A selective, accurate and simple high performance liquid chromatography (HPLC) method was established and the plasma concentration profiles and pharmacokinetic parameters of γ-schisandrin in rats were investigated after oral administration of WSD and CSP. The results revealed that the bioavailability of γ-schisandrin in rats administrated WSD increased significantly compared with the CSP. The pharmacokinetic results of γ-schisandrin in rats after i.g. WSD or CSP demonstrated the existence of marked gender-dependent differences. The Cmax and AUC values of γ-schisandrin in female rats after i.g. WSD and CSP were found to be about 3-fold and 6-fold higher, respectively, than those in male rats. This gender difference could be helpful in determining the appropriate dosage of WSD and its preparations. Related Articles | Metrics Cited: Baidu(5) Select Pharmacognostical study of Folium Schisandrae chinensis Bin Xiao;Xuehan Liu;Di Hu;Chihui Liu;Xiaokang Wang;and Jun Yin * null    2007, 2 (5): 198-201.   Abstract （1482）            Knowledge map    This paper reports microscopic observations of Folium Schisandrae chinensis (Magnoliaceae) and the TLC identification of and determination of its total lignan quantities which should lay the foundation for the future usage and development of compounds from a different plant source. Related Articles | Metrics Cited: Baidu(4) Select Antipyretic activity studies of two botanical sources of the drug Murva V. Madhavan;Amit Kumar Shukla;Anita Murali;Usha M;S. N. Yoganarasimhan* null    2010, 5 (5): 171-180.   Abstract （2330）            Knowledge map    Murva is one of the controversial drugs used in Ayurvedic medicine. In the present study two botanical sources of Murva, viz. Wattakaka volubilis and Maerua oblongifolia, were tested for antipyretic activity by yeast-induced pyrexia in Wistar albino rats. Alcohol and aqueous extracts of both species significantly reduced the elevated rectal temperature in febrile rats within 30 min of their administration. The results of these studies support the traditional use of these two botanical sources of the drug Murva in the treatment of fever. Related Articles | Metrics Cited: Baidu(4) Select Phytochemical, safety and pharmacokinetic profile of Jawarish-e-Bisbasa: a potent unani medicine for gastric disorders Sunita Shailajan *;Sasikumar Menon;Neelam Sayed;Harshvardhan Joshi;Bhavesh Tiwari null    2012, 7 (4): 168-177.   Abstract （903）            Knowledge map    Jawarish-e-Bisbasa, an Unani polyherbal formulation, is used traditionally in the clinical treatment of stomach ulcers, weakness of digestion, piles, flatulence, nausea, gastritis and as an energy enhancer for stomach. In the current work; phytochemical, safety and pharmacokinetic profile of Jawarish-e-Bisbasa has been evaluated. Phytochemical constituents in Jawarish-e-Bisbasa were qualitatively evaluated using standard tests. Safety of the formulation was affirmed by conducting acute oral toxicity in mice. Chemical characterization was carried out on the basis of piperine content. A simple HPLC method was developed for determination of piperine in rabbit plasma and applied to study the pharmacokinetics of piperine after oral administration of aqueous slurry of Jawarish-e-Bisbasa in rabbits. Jawarish-e-Bisbasa showed the presence of flavonoids, essential oils, tannins, glycosides, alkaloids and resins. It did not show any evident toxicity in mice. Piperine content in Jawarish-e-Bisbasa was 0.15±0.004 mg/g using HPLC. Piperine was detected in rabbit plasma with Cmax and Tmax of 79.21±1.24 ng/ml and 0.75±0.00 h respectively post administration of Jawarish-e-Bisbasa. The current work demonstrates a modern approach towards standardization of traditional Unani formulation Jawarish-e-Bisbasa. Related Articles | Metrics Cited: Baidu(3) Select Effect of chronic administration of chloroquine on the gastrocnemius muscle, spleen and brain of Swiss albino mice K. R. Desai *;J. J. Dattani;D. K. Rajput;N. Moid;B. J. Yagnik;H. N. Highland;L. B. George null    2010, 5 (2): 62-69.   Abstract （1076）            Knowledge map    The aim of the present study was to investigate the influence of chloroquine on some vital tissues of mice (Mus musculus). Healthy adult male Swiss albino mice weighing between 30-40 g were used for the study. Treated group was exposed to 200 mg/kg body weight/day of chloroquine phosphate given orally for 45 days. Control animals were given distilled water for the same period. Gastrocnemius muscle, spleen and brain tissues were biochemically investigated post-treatment. The results obtained showed a significant increase in protein levels of the gastrocnemius muscle (P<0.001), brain (P<0.001) and spleen (P<0.05). The total lipid content of both muscle and brain showed a highly significant increase (P<0.001) while the cholesterol level was increased significantly (P<0.05) only in spleen. Ascorbic acid also exhibited a significant increase (P<0.001) in muscle. Histological examination of muscle and spleen also revealed concomitant changes in histoarchitecture. Thus the use of choloroquine for longer periods requires strict monitoring as chronic usage may lead to the development of many detrimental effects in the host. Related Articles | Metrics Cited: Baidu(3) Select Anxiolytic Effect of Baicalin in Mice Xiuyan Wei;Jingyu Yang;Chunfu Wu* null    2006, 1 (3-4): 150-154.   Abstract （2793）            Knowledge map    The present study compared the putative anxiolytic effect of baicalin, one of the active principles isolated from Huangqin ( Scutellariae Radix ), a Chinese herbal drug, with diazepam in mice by using the elevated plus-maze test, the light/dark test, the hole-board test and the isolationinduced aggression test. Both baicalin ( 80 mg/kg, i.p. ) and diazepam ( 2.5 mg/kg, i.p. ) reduced the total fighting time in the isolation-induced aggression test. Baicalin ( 40 and 80 mg/kg, i.p. ) and diazepam ( 2.5 mg/kg, i.p. ) increased the percentage of time and entries spent in open arms in the elevated plus maze and increased the time spent in the light area of the light/dark box. In the hole-board test, baicalin ( 40 or 80 mg/kg, i.p. ) and diazepam ( 2.5 mg/kg, i.p. ) significantly increased both head-dip counts and head-dip duration and reduced head-dip latency. Thus, the present findings indicate that baicalin has an anxiolytic effect. Related Articles | Metrics Cited: Baidu(3) Select Determination of Pyrethroid Pesticide Residues in Traditional Chinese Medicines by Gas Chromatography-Mass Spectrometry with Negative Chemical Ionization He Zhu;Yuehu Pei*;Aihua Song null    2006, 1 (2): 55-59.   Abstract （419）            Knowledge map    A method is described for determining and screening 5 pyrethroid pesticides in 48 kinds of traditional Chinese medicines, each as 10 batches, by gas chromatography–mass spectrometry (GC-MS) with negative chemical ionization (NCI). The method had been tested for 5 pesticides in 6 traditional Chinese medicinal plants with limits of detection (LODs) from 0.5ppb to 5ppb. The recoveries of the 5 pesticides in the 6 plants ranged from 70% to 120% with relative standard deviations < 10% . The method is rapid, sensitive and suitable for the analysis of large numbers of samples at the same time. Related Articles | Metrics Cited: Baidu(3) Select The stimulatory activity of three steroidal glycosides on osteoblast proliferation Jun Yin *; Ying Wang;Zhihui Liu;Na Han;and Shigetoshi Kadota null    2007, 2 (4): 159-161.   Abstract （1653）            Knowledge map    Three compounds were extracted from the rhizomes of Dioscorea spongiosa and identified as pregnadienolone 3-O-β-chacotrioside, pregnadienolone 3-O-β-gracillimatriose and hypoglaucin G, respectively. The compounds were isolated and purified by silica gel column chromatography and normal- and reversed-phase preparative TLC, and their chemical structures were determined by NMR and MS. Their stimulatory activity on the proliferation and mineralization of osteoblasts is reported in this paper. Related Articles | Metrics Cited: Baidu(2) Select Quality Control of TCMs Using a Chromatographic Fingerprint Ying Jia;Xiaojie Tan;Qing Li;Weiming Cheng;Xiaohui Chen;and Kaishun Bi* null    2006, 1 (2): 94-100.   Abstract （1388）            Knowledge map    This paper summarizes the application of a chromatographic fingerprint for the quality control of TCMs (traditional Chinese medicines) and illustrates its application to TCM quality control by taking Flos Chrysanthemi Indici injection and Danhong injectable powder as examples. Related Articles | Metrics Cited: Baidu(2) Select A New Tetrahydrofuran Lignan Glycoside from Viscum coloratum Jun Yin *;Xiaokang Wang;Zhihui Liu;Shigetoshi Kadota null    2007, 2 (2): 58-60.   Abstract （1615）            Knowledge map    A new tetrahydrofuran lignan glycoside, named viscoloratin, was isolated from the stem of Viscum coloratum (Komar.) Nakai. Its structure was elucidated by spectroscopic analysis and chemical methods. Related Articles | Metrics Cited: Baidu(2) Select Anti-metabolic syndrome effect of Licorice flavonoid dispersible tablets in a high fat diet-induced obesity/ type 2 diabetes mouse model Zijiao Ma;Ying Xu;Yingkai Zhang;Li Dong;Qian Li;Qiuyan Duan;Jinjun Xu;Jingman Ni * null    2010, 5 (3): 89-101.   Abstract （1145）            Knowledge map    Licorice flavonoids are readily obtained from the traditional Chinese herbal medicine Glycyrrhiza uralensis Fischer. In this study, the effects of licorice flavonoid dispersible tablets (LFT) on visceral fat accumulation, hyperglycemia, fatty liver, and related adipocytokines in high-fat diet-fed C57BL/6J mice were examined. The results showed that mice fed a high-fat diet exhibited a significant increase in fasting blood glucose, serum insulin, leptin level, visceral fat accumulation, and body weight, which were markedly inhibited after an 8-week treatment with LFT. Furthermore, LFT had a potential liver- protective effect and a dose-independent effect on suppressing adipocyte hypertrophy and promoting adipocyte differentiation. Therefore, these results suggest that LFT could be developed as a potential reagent to treat metabolic syndromes such as obesity and type 2 diabetes. Related Articles | Metrics Cited: Baidu(2) Select Physicochemical evaluation and essential oil compositionanalysis of Bidens parviflora Willd. from China Hongyan Liu* null    2013, 8 (1): 20-25.   Abstract （548）            Knowledge map    The aerial part of Bidens parviflora Willd is well-known as Guizhencao in traditional Chinese folk medicine for the treatment of ailments such as diabetes, hepatitis, enteritis, laryngitis, etc. The essential oil of B. parviflora was obtained by hydrodistillation and further analyzed by GC-MS method. Physicochemical investigation was also carried out on this medicinal plant. The yield of essential oil was 0.09% (v/w). Sixty-one constituents accounting for 89.37% of the total oil were identified and quantified. The total ash value, acid-insoluble ash value, water-soluble, ethanol-soluble, ether-soluble extractive and moisture content values are 8.75%, 1.25%, 25.87%, 19.85%, 0.30% and 9.41%, respectively. The pharmacognostical parameters could be used as the diagnostic tool for the standardization of this medicine and the results also can be considered as the identifying parameters to substantiate and authenticate the drug. Related Articles | Metrics Cited: Baidu(2) Select 2, 3, 9, 10-Tetraoxygenated Protoberberine Alkaloids from Corydalis yanhusuo W. T. Wang Yang Qu;Min Liu;Zhaohua Wu;Huiyuan Gao;Bohang Sun;Qiuju Su;Lijun Wu * null    2007, 2 (2): 61-65.   Abstract （2040）            Knowledge map    Five alkaloids with the skeleton of 2, 3, 9, 10-tetraoxygenated protoberberine identified as tetrahydrocorysamine (1), tetrahydrocoptisine (2), corydaline (3), tetrahydropalmatine (4), and dehydrocorydaline chloride (5) were isolated from the bulbs of Corydalis yanhusuo W. T. Wang. Among them, tetrahydrocorysamine was isolated from this plant for the first time. The 1H and 13C NMR spectra signals of these compounds were assigned completely based on 2D NMR spectrum. Some errors of the data in the references were revised. Related Articles | Metrics Cited: Baidu(2) Select Simultaneous quantification of four major bioactive anthraquinones in Dangguilonghui Tablets by high-performance liquid chromatography Chunli Hu;Yi Jin;Peng Zhang;Huaiqing Zhao * null    2008, 3 (2): 52-57.   Abstract （2732）            Knowledge map    A high-performance liquid chromatographic (HPLC) method was developed for the simultaneous determination of four anthraquinones, rhein, emodin, chrysophanol and physcion, in Dangguilonghui Tablets (as traditional Chinese medicine). The optimal conditions involved separation on a Diamonsil-C18 column (200 mm×4.6 mm, 5 μm) with a mobile phase composed of methanol: 0.1 % phosphoric acid (180:20, v/v) and detection at 254 nm. Excellent linearity was obtained over the investigated concentration ranges, with the values of R2 higher than 0.999 for all the analytes. The recoveries, measured at three concentration levels, varied from 99.8 % to 101.2 %. The results indicate that the method is reproducible, precise and can be used for the quality control of Dangguilonghui Tablets Related Articles | Metrics Cited: Baidu(2) Select A preliminary antihyperglycemic andantinociceptive activity evaluation of a mangrovespecies Acanthus ilicifolius L. leaves in mice Md Nasir Ahmed, Tanzina Sultana, Md Nur Kabidul Azam, Mohammed Rahmatullah Asian Journal of Traditional Medicines    2014, 9 (6): 143-149.   Abstract （493）            Knowledge map    The antihyperglycemic and antinociceptive activity of methanolic extract of Acanthus ilicifolius leaves was assessed, respectively, through oral glucose tolerance tests, and acetic acid-induced pain model in Swiss albino mice. The extract, when administered to mice at doses of 50, 100, 200 and 400 mg per kg body weight, dose-dependently reduced blood glucose levels in glucose-loaded mice, respectively, by 39.6, 42.2, 48.0, and 50.1%. A standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight reduced blood glucose level by 50.1%. Thus the extract, at the highest dose tested, showed equivalent antihyperglycemic potency to that of glibenclamide. At the afore-mentioned four doses, the extract reduced the number of abdominal constrictions induced by intraperitoneal administration of acetic acid in mice by 43.9, 51.2, 56.1, and 58.6%, respectively. By comparison, a standard antinociceptive drug, aspirin, when administered to mice at a dose of 200 mg per kg body weight, reduced the number of abdominal constrictions by 34.1%, demonstrating that the extract, even at the lowest dose, was more potent than aspirin. The results suggest that leaves of the plant possess phytochemical constituents with antihyperglycemic and antinociceptive activities, and which merits further isolation and identification. Related Articles | Metrics Cited: Baidu(2) Select Evaluation of galactagogue and antioxidant activitiesof the root extract of Euphorbia fusiformis Sumit Manna;Tapas K. Sur;Tapan Seal;Anirban Roy * null    2013, 8 (5): 119-128.   Abstract （545）            Knowledge map    Present communication deals with antioxidant activity of acetone and methanol extracts and evaluation of galactagogue activity of alcoholic extract of the roots of Euphorbia fusiformis, a rare medicinal herb traditionally used by the Santal tribe of Gonpur forest area, West Bengal, India. Phenolic content was estimated following Folin-Ciocalteu procedure. Flavanoids and flavonols content were also measured using standard protocols. 1, 1 diphenyl-2-picrylhydrazyl radical scavenging effect of the two different extracts were determined spectrophotometrically. Fifteen lactating rats were equally distributed into three groups. Control group rats were treated with 2 ml/kg distilled water, Group II and III rats were orally administered 250 and 500 mg/kg body weight, respectively, of ethanolic extract of the root of Euphorbia fusiformis from 3rd to 15th day of parturition. On 16th day, blood samples from mother rats were collected. Glycogen and total protein content in mammary gland and serum prolactin were estimated. Highest phenol content and radical scavenging with IC50 = 0.240±0.001 mg dry material was found in acetone extract of plant. Methanol extract contain a very good amount of flavanoids and flavonols. Alcoholic extract significantly increases milk yield, pups’ body weight, glycogen and protein content of mammary gland tissue, and serum prolactin, compared to control animals. Greater amount of phenolic compounds leads to more potent radical scavenging effect as shown by acetone extract of plant. Euphorbia fusiformis possesses significant antioxidant activity, and the bioactive constituents stimulate secretion/ regulation of prolactin hormone and thereby may regulate the formation of milk. Related Articles | Metrics Cited: Baidu(1) Select Ethnomedicinal plants of the Var tribe of Bangladesh Akmal Hossain Nipu;Sahara Akter;Humayra Naz Chyti;Protiva Rani Das;MdTabibul Islam;Mohammed Rahmatullah* null    2014, 9 (2): 25-33.   Abstract （549）            Knowledge map    The tea estates of Moulvibazar district of Bangladesh are hot spots for finding many small tribes (100-500 community members), which tribes are not found elsewhere in the country. It was the objective of the present study to document the tribal medicinal practices of the Var tribe of Moulvibazar district. The Var tribe can be found as a single community residing in Kamalganj tea estate in Moulvibazar district. Interviews of the two tribal healers were carried out with the help of a semi-structured questionnaire, open-ended interviews, and the guided field-walk method. The tribe had less than 200 community members. The two healers used a total of 25 medicinal plants distributed into 20 families for treatment of various ailments, which included fever, gastrointestinal disorders, wounds, ear problems, low sperm count, coughs, itches, and menstrual pain. One formulation was used as a galactagogue. From the number of plants used, it appeared that low sperm count, coughs, and gastrointestinal disorders were the major ailments faced by the tribal community. Available scientific reports validate the use of several plants by the traditional healers. Further scientific validation of the various therapeutic uses of medicinal plants by the tribal healers can be an effective approach to make cheap medicines readily available to the tribal community, who are too poor to afford allopathic medicines. Related Articles | Metrics Cited: Baidu(1) Select Pharmacognostical studies on the leaves ofBasilicum polystachyon Moench Varadharajan Madhavan;Sunkam Yoganarasimhan *;Rajendra Prasad;Magadi Gurudeva;Rajamanickam Deveswaran null    2013, 8 (1): 11-19.   Abstract （734）            Knowledge map    Basilicum polystachyon is an important medicinal plant. The leaves are used in the treatment of epilepsy, palpitation of heart, neuralgia and as a sedative. The pharmacognostical evaluation of the leaf of B. polystachyon which is used for medicinal purposes is presented in this paper. The study includes the morphology of the plant, macro-, microscopical characteristics of the leaf, macerate elements, histochemical and UV studies, physico-chemical constants and phytochemical analysis. The findings like the presence of diacytic type of stomata, trichomes of glandular, non-glandular, uni- and multicellular types, thick walled collenchyma cells and abundant oil droplets are the characters which help in the identification of this leaf drug. Preliminary phytochemical analysis revealed that pet. ether extract contained phytosterols; alkaloids, carbohydrates, glycosides and phytosterols were present in alcohol extract; alkaloids, carbohydrates, glycosides, volatile oils, gums and mucilage were found in water extract; alkaloids and phytosterols were found in acetone extract while no phytoconstituent was present in chloroform extract. HPTLC finger print profile of alcohol and aqueous extracts has been carried out which helps in the identification of the biomarker compound. These studies contribute towards establishing pharmacopoeial standards for the drug. Related Articles | Metrics Cited: Baidu(1) Select Wound healing efficacy of a polyherbal ointment used to treat incisions, excisions and burn wounds in albino rats Elakiya Ponnusamy ;Jothi Gnanasekaran *;Radhika Jeyaraman null    2012, 7 (4): 151-158.   Abstract （961）            Knowledge map    The present study was carried out to evaluate the wound healing efficacy of a herbal ointment formulated with Madhuca indica L., Ziziphus mauritiana Lam., Calendula officinalis Linn. and Moringa pterygosperma Gaertn. embedded in an ointment base and used to treat incisions, excisions and burn wounds in an albino rat model. The rats were Wistar strain weighing 150-200 g which were divided into 9 groups each of 6 rats. Groups I, IV and VII served as wounded controls, Groups II, V and VIII were wounded and treated with Polyherbal Ointment (PHO) topically. The wound healing effect was evaluated in comparison with a reference ointment Soframycin, for excisions (Group III) and incisions (Group VI) and Burnol (Group IX) for burn wounds. The Polyherbal ointment (PHO) treated group showed a faster rate of wound contraction compared with the control groups. Topical application of the Polyherbal ointment in treated groups produced a significant increase (P<0.05) in wound breaking strength, hydroxyproline, hexosamine, protein, DNA, RNA and Superoxide Dismutase (SOD) levels. It also significantly reduced the level of Lipid peroxide (LPO) when compared with the control groups. Histological studies of the tissue from the PHO treated group showed increased and well organized bands of collagen, more fibroblasts and fewer inflammatory cells when compared with the control groups. These results strongly support the belief that the Polyherbal ointment (PHO) has antioxidant properties which may be responsible for and promote faster wound healing in rats at an effective topical dosage. Hence PHO is an economical option for wound treatment. Related Articles | Metrics Cited: Baidu(1) Select A comparative study of isolated flavonoid and different extracts of Caesalpinia pulcherrima (L) Sw. for in vitro immunomodulatory effects on human neutrophils Smita Daniel Madagundi *;Manjunath Karibassapa Pawadshetter;Hasan Pasha Sholapur;Prasanna Habbu;Siddaruda Malleshappa Biradar null    2012, 7 (4): 159-167.   Abstract （916）            Knowledge map    The in vitro immunomodulatory activity of leaves of Caesalpinia pulcherrima (L) Sw. extracts on human neutrophils was carried out in the present study. The total alcoholic, petroleum ether, ethyl acetate, n-butanol, acqueous extract and isolated flavonoid (F-1) compound of Caesalpinia pulcherrima (L) Sw. were screened for their possible immunomodulatory activity by assessing nitroblue tetrazolium test, phagocytosis of killed Candida albicans, candidacidal assay, neutrophil locomotion and chemotaxis. All the extracts were tested at concentration of 10 mcg/ml, 100 mcg/ml, 250 mcg/ml, 500 mcg/ml and 1 mg/ml. The total alcoholic, petrolium ether, Ethyl acetate , n-butanol, aqueous extract and isolated compound showed predominantly significant activity on in vitro human neutrophils in all studied parameters, which are comparable to standard and control at different concentration indicating the possible immunostimulating effect. So the results of the investigations justify that the immunomodulatory activity on human neutrophils may be due to flavonoid present in ethyl acetate extract. Hence this study provides the basic platform to develop an herbal-formulation in the management of immune disorders. Related Articles | Metrics Cited: Baidu(1) Select Chemistry, fate and chemopreventive actions of Sulphoraphane Shah A. Khan *;Aftab Ahmad;Yaseen M. Al Lawatia null    2012, 7 (6): 275-291.   Abstract （587）            Knowledge map    Numerous studies suggest that a high consumption of cruciferous vegetables, especially broccoli and broccoli sprouts, can protect against various forms of cancer. The chemo-preventive actions of these cruciferous vegetables have been attributed to sulphoraphane (SFN), a naturally occurring isothiocyanate which they contain. In humans, glucoraphanin isothiocyanate is hydrolyzed by an enzyme, myrosinase, to yield an active metabolite, SFN. Sulphoraphane has been proven to offer protection against oxidative damage and carcinogens. It is also a potent inducer of phase II detoxification enzymes and an inhibitor of phase I enzymes that are involved in the activation of certain carcinogens in body. It also modulates many cancer-related events including, cell death, cell cycle, angiogenesis, invasion and metastasis, making it a highly promising agent for cancer prevention and treatment. The aim of this brief review is to provide updated information to improve our understanding of the chemistry, synthesis and biosynthesis, metabolism and chemoprevention mechanisms of SFN. Related Articles | Metrics Cited: Baidu(1) Select Analysis of the compounds present in rat blood after oral administration of the extract of Gushudan (a Chinese compound prescription) Man Liu;Huiping Liu;Xiumei Lu;Zhili Xiong;Famei Li * null    Select Development of a chromatographic fingerprint for the quality control of Radix Puerariae Guogang Zhang *;Ping Li;Jifei Chi;Tiantian Zuo;Shengchao Wang;Li Li null    2008, 3 (2): 67-75.   Abstract （2897）            Knowledge map    A simple, reliable and reproducible method, based on high performance liquid chromatography (HPLC), for developing a chromatographic fingerprint of the herbal medicine Radix Puerariae is described. To establish the analytical method for Radix Puerariae, fingerprints of 13 batches of P. thomsonii Benth. and 4 batches of Pueraria lobata (Willd.) from different places were studied and compared by means of “The Similarity Calculation Soft of Fingerprint Chromatography of Traditional Chinese Medicine”. The study also established the fingerprint for the herbs, and some peaks were assigned by comparison with reference compounds. The precision, reproducibility and stability all satisfied the requirements of national standards for fingerprint development. A method for the determination of the quality of the herbs was established. There is increasing interest in the use of the kudzu root (Radix Pueraria) dietary supplements. Standardization of the analytical method to establish fingerprints for each species and the effects of growing areas is needed. Related Articles | Metrics Cited: Baidu(1)