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    Protective effect of BlingLife®-berry extract on blue light-induced eye damage and its mechanism
    Jiaxiang Ding, Chenfeng Shou, Kexin Xie
    Asian Journal of Traditional Medicines    2024, 19 (1): 1-9.  
    Abstract40)      PDF(pc) (2200KB)(34)      
    This study aims to investigate the protective effects of BlingLife®-berry extract on the eyes. BlingLife®-berry extract is a mixture of high-quality natural berries, including blackcurrant, aromia, bilberry and maquiberry. The main active ingredient responsible for theeye-protective effects is anthocyanins. Anthocyanins are natural water-soluble pigments belonging to the flavonoid class, and theyhave multiple benefits, including improving vision, anti-inflammatory and antibacterial properties, and antioxidant effects. Dueto the dual benefits of anthocyanins in protecting vision and eliminating free radicals, this study explores the comprehensive eye protective effects of BlingLife®-berry extract in terms of combating blue light-induced eye damage and oxidative stress-inducedvisual fatigue. The results provide robust evidence for the in vivo effects and further technological
    applications of BlingLife®-berry extract.
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    Analysis of plant resources and diversity in Balluk Mountain, Xinjiang Uygur Autonomous Region
    Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (1): 10-25.  
    Abstract12)      PDF(pc) (538KB)(16)      
    Balluk Mountain is located between the Tianshan Mountains and the Altai Mountains in Xinjiang Province. Influenced by the humid air and diverse landforms of Lake Alacuri, the unique climate of Mount Baluk nourishes excellent pastures and supports numerous wildlife, making it rich in plant resources. The 9th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team conducted field investigations, literature reviews, and specimen identification to study the plant resources and diversity of Balluk Mountain in Xinjiang Province. A total of 235 species of medicinal plants belonging to 59 families and 159 genera were collected during the period from July to August 2015 in this area. The dominant families observed were Asteraceae, Caryophyllaceae, Lamiaceae, Ranunculaceae, Rosaceae and Umbelliferae, with 35, 11, 14, 12, 27, and
    13 species respectively. These families account for over 47.4% of the total species collected, though comprising only 10.2% of the total number of families. At the genus level, Artemisia was found to be the most dominant genus with eight species, contributing to 0.63% of the total genera, while representing 3.4% of the total species abundance. Overall, this study provides an updated analysis of the plant resources and diversity in Balluk Mountain. Several species have been identified to possess significant medicinal properties and hold potential for various research fields, including natural product chemistry and drug development. The study also offers practical and meaningful suggestions for strengthening the protection and utilization of plant resources in the area. By implementing these suggestions, we can better preserve the plant diversity in Balluk Mountain and ensure the sustainable use of these valuable resources.
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    Investigation and analysis of vascular plant resources and diversity in Wuyi Mountain, Fujian Province
    Peiying Chen, Ruru Xiong, Jun Yuan, Minglong Huang, Zhuo Tao, Bowen Zhang, Fanglin Luo, Lisha Liu, Qian Wang, You Zhou, Haofan Zhang, Zijie Wei, Jie Yang, Jiangang Chen, Kui Wu, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (1): 26-33.  
    Abstract19)      PDF(pc) (632KB)(11)      
    Wuyi Mountain, located in the north of Fujian Province, China, is renowned for its abundant medicinal plant resources. In July 2014, the 8th (second team) of Shenyang Pharmaceutical University’s Chinese Medicine Resources Scientific Expedition Team conducted field investigation in the area. Through specimen collection and extensive literature review, the team identified and analyzed 223 vascular plant species from 175 genera and 85 families. The most dominant families were Compositae and Rosaceae, and perennial herbs were the predominant species, accounting for 44.39% of the total species identified. Notably, we documented five precious and rare medicinal plants unique to Wuyi Mountain. This study updates the database of plant resources and diversity in the region, providing a valuable reference for future studies. Finally, we put forward some suggestions to enhance the conservation and sustainable utilization of Wuyi Mountain’s plant resources.
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    Chemical constituents and pharmacological effects of Lonicerae japonicae
    Yunpeng Yang# , Dan Tian# , Yibo Wang, Yi’an Shi, Yuntian Xing, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (1): 34-45.  
    Abstract18)      PDF(pc) (1416KB)(9)      
    Lonicera japonica, also known as honeysuckle, is an evergreen shrub in the family of Syzygium. By consulting Sciencedirect databases and Web of Science databases, 79 related articles were found, of which 22 were related to chemical composition and pharmacological activity. These articles show that L. japonica has a wide range of pharmacological activities, including antiviral, anti-tumor, and antioxidant effects. These activities have important applications in the pharmaceutical, food, and fragrance industries. This review focuses on the chemical composition and pharmacological effects of L. japonicae, which is of great significance to the development of new drugs and therapeutic methods.
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    Analysis of wild vascular plant resources and diversity in Taibai Mountains of Qinling area, Shaanxi Province
    Bingjun Sun , Qing Wang , Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (6): 253-270.  
    Abstract34)      PDF(pc) (4931KB)(42)      
    Taibai Mountains, located at the northern foot of the Qinling Mountains, are composed of the Yuan Taibai Mountain (also known as East Taibai Mountain), Aoshan Mountain (also known as West Taibai Mountain) and their connection part. With its complex geographical and climatic conditions, Taibai Mountains are extremely rich in wild plant resources. Based on field investigation, literature review and specimen identification, wild vascular plants resources and their diversity in Taibai Mountains were studied by the sixth Traditional Chinese Medicine (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University. 222 species of vascular plants belonging to 163 genera and 63 families were collected during July 2012 in this area, and most of the plants are angiosperms. The families with more species are Liliaceae, Ranunculaceae, Asteraceae, Rosaceae, and Saxifragaceae, and the dominant genus are Aconitum, Sedum, Eleutherococcus, Pedicularis, Polygonatum, and Patrinia. In terms of life form, perennial herbs are the main species, accounting for 72.97% of the total species, with others being some annual (or biennial) herbs, shrubs and lianas. Among all the collected vascular plants, 170 species of them are medicinal vascular plants, accounting for 76.58% of the total. Most of the medicinal parts are roots and rhizomes, followed by the whole plants. Finally, on the basis of investigation and study, some suggestions are put forward to strengthen the protection and utilization of plant resources in Taibai Mountains.
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    Analysis of vascular plant resources and diversity in Machin County, Qinghai Province
    Hu Chen, Dongdong Wang, Qing Wang, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (6): 271-279.  
    Abstract25)      PDF(pc) (1240KB)(23)      
    Machin County is situated in the Sanjiangyuan Nature Reserve in the southeastern part of Qinghai Province. Influenced by the special topography and climate of the Qinghai-Tibet Plateau, Machin County has complex and diverse plant species. The vascular plant resources and diversity in Machin County were studied through field survey, literature review and specimen identification. The results show that there are 47 families and 127 genera and 256 species of vascular plants in the region, basically angiosperms, including those containing more species of the family Asteraceae, Buttercup, Genus Ginseng, Leguminosae and Rosaceae, and those containing more species of the genus Artemisia, Artemisia, Aster and Donzonia. In terms of life type, perennial herbs are the most dominant ones, accounting for 77.34% of the total number of species, followed by some annual (or biennial) herbs and shrub types. There are 191 species of medicinal vascular plants, accounting for 74.61% of the total number of species, including 48 species of Tibetan medicine. In terms of the medicinal parts of these plants, whole herb category is the most common one, followed by the root and rhizome category. Based on the investigation and research, we have proposed the conservation and utilization of plant resources in Machin County, Qinghai Province.
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    Chemical composition and biological activities of volatile oil isolated from Curcumae rhizoma
    Wenhan Wang, Yibo Wang, Yuntian Xing, Xinyao Wang, Guanyi Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (6): 280-288.  
    Abstract37)      PDF(pc) (1008KB)(27)      
    Curcumae rhizoma (C. rhizoma), the rhizome of Curcuma Longa L., Curcuma kwangsiensis L. and Curcuma wenyujin L. in the ginger family, is a treasure in traditional Chinese medicine. It has the effect of promoting qi and breaking blood, eliminating accumulation and relieving pain. With the development of modern medicine, the active ingredients and therapeutic mechanism of C. rhizoma have been gradually revealed. In this paper, the chemical composition and biological activities of volatile oil isolated from C. rhizoma are reviewed in detail, aiming to provide reference for further utilization of C. rhizoma volatile oil and provide more effective drug options for clinical treatment.

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    Computational investigation on the molecular structure and chemical reactivity of a traditional Chinese medicine extract MK-1 molecule
    Jian Zhang
    Asian Journal of Traditional Medicines    2023, 18 (5): 209-217.  
    Abstract48)      PDF(pc) (2925KB)(85)      
    MK-1 molecule (C 16 H 16 O 2 ), the simplest structure of vitamin K (VK) compound family, is an extract from traditional Chinese medicine Cymbopogon distans (Nees ex Steud.) Wats (Chinese name YunXiangCao), which has attracted a great deal of attention in recent years due to its antiasthmatic, antitussives and expectorant effects. To investigate the molecular structure and chemical reactivity of MK-1 molecule, computational investigations on six conformational minima structures were carried out at the MP2/6-311++G(2d,2p) level of theory. Several local reactivity descriptors including condensed Fukui function, average local ionization energy, and molecular electrostatic potential on each individual atom were determined to predict the intrinsic reactivity of MK-1 molecule.
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    Research progress on chemical constituents and pharmacological effects of medicinal plant Gynostemma pentaphyllum
    Yibo Wang, Yi’an Shi, Guanyi Zhao, Shuo Wang, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (5): 218-235.  
    Abstract47)      PDF(pc) (4538KB)(59)      

    Gynostemma pentaphyllum (G. pentaphyllum) is a traditional medicinal plant with medicinal and economic value. With in-depth research on the chemical compositions and pharmacological effects, the applications of G. pentaphyllum have been expanded. G. pentaphyllum has the effects of clearing heat and detoxification, relieving cough and phlegm, nourishing heart, tranquilizing nerves, and can be used to treat gastroenteritis, tracheitis, pharyngitis, hyperlipidemia, and arteriosclerosis. It can also be used to alleviate symptoms such as migraines, insufficient sleep, and white hair. In recent years, G. pentaphyllum has also been used for clinical adjuvant treatment of various cancers. In this study, the chemical constituents and pharmacological effects on G. pentaphyllum in recent years were reviewed. This review could provide reference for further development and utilization of G. pentaphyllum.

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    Investigation on vascular plant resources and their diversity in Wuzhishan, China
    Peiying Chen, Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (5): 236-245.  
    Abstract42)      PDF(pc) (1278KB)(28)      
    Wuzhishan, located in the central part of Hainan Island and characterized by undulating terrain and diverse vegetation, is rich in plants. In October 2020, field investigations were carried out by the 14th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team. Through specimen collection and literature retrieval, the team collected and analyzed vascular plants, resulting in the identification of 455 species belonging to 328 genera in 145 families. The dominant families are Leguminosae, Malvaceae, Compositae, Rubiaceae, Lauraceae, Pteridaceae, and Polypodiaceae. The main dominant species were perennial herb, comprising 147 species, 32.31% of the total. From the 367 species of medicinal vascular plants, the team screened and recorded 20 species of Li medicine according to indications of the medicinal use and the part of the plant used. As a result, the dominant families of vascular plants were similar to medicinal vascular plants, which means vascular plants is an important medicinal resource in Wuzhishan. Based on the investigation and research, further suggestions were made to strengthen the conservation and utilization of plant resources in Wuzhishan.
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    Evaluation of the effect of shodhana (detoxification) process using chromatographic profiling (HPTLC, HPLC, LC-MS, and GC-MS) and estimation of the content of toxic colchicine in Gloriosa superba Linn. tubers
    Ajay Kumar Meena, Poorna Venktaraman, Mohit Motiwale, Ravindra Singh, Kusuma Ganji, N. Srikanth, K. S. Dhiman
    Asian Journal of Traditional Medicines    2023, 18 (4): 143-162.  
    Abstract154)      PDF(pc) (6977KB)(96)      
    Shodhana (purification/detoxification) is an important aspect of Ayurveda. It has been described in several important pieces of literature. In this study, we performed shodhana process on Langali (Gloriosa superba Linn.) tubers of family Liliaceae, a semi-woody herbaceous climber with significant therapeutic properties. We compared the unprocessed (before purification) and processed (after purification) samples based on the phytochemical, physicochemical, and chromatographic study, including HPTLC, HPLC, GC-MS and LC-MS. Significant changes were observed in profiling after the shodhana process. This plant contains colchicine, known for its toxic effects, particularly cardiotoxicity. Therefore, we quantified colchicine in the unprocessed and processed samples of Gloriosa superba Linn. tubers using HPLC method. Results showed that the percentage of colchicine was reduced by 13.67% in chloroform extract and 20.97% in ethanol extracts after the shodhana process.
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    Application of Caenorhabditis elegans in screening active ingredients of traditional Chinese medicine
    Ling Zhao, Mengyue Zhang, Yingying Wu, Rutian Jin, Lingxuan Li, Ying Long, Xin Wu
    Asian Journal of Traditional Medicines    2023, 18 (4): 163-172.  
    Abstract152)      PDF(pc) (1898KB)(167)      
    People continue to recognize the important role of Chinese medicine in the treatment of diseases, and there is an urgent need to clarify the mechanism of Chinese medicine. Because of the multi-target and multi-component characteristics of traditional Chinese medicine, it is difficult to elaborate from a single perspective. As a high-quality animal model, Caenorhabditis elegans with the characteristics of small size and fast reproduction, has been widely used in traditional Chinese medicine activity experiments. In this article, Caenorhabditis elegans, as model organisms used to screen the active components of traditional Chinese medicine were reviewed.
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    Chemical composition and biological activities of Portulaca oleracea
    Haonan Yu, Yi’an Shi, Yibo Wang, Yunpeng Yang, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (4): 173-202.  
    Abstract146)      PDF(pc) (1051KB)(64)      
    Portulaca oleracea (P. oleracea) is a traditional Chinese herbal that has the effects of soothing the liver and clearing collaterals, strengthening the spleen and stomach, moistening the intestines and detoxifying. With the development of the pharmaceutical industry, the medicinal value of P. oleracea is becoming increasingly prominent. It is commonly used in clinical practice for clearing heat and detoxifying, inhibiting bacteria, preventing and treating diseases such as hypertension, coronary heart disease, and cerebral infarction, indicating its broad application prospects. This study reviews the chemical components and pharmacological activities of P. oleracea in recent decades.
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    Mechanism of Cinnamomum camphora essential oil for analgesia based on gas chromatography-mass spectrometry integrated network pharmacology
    Nianyun Yang
    Asian Journal of Traditional Medicines    2023, 18 (3): 87-97.  
    Abstract353)      PDF(pc) (4328KB)(166)      
    This study aims to explore the analgesic ingredients and mechanism of Cinnamomum camphora essential oil (CCEO). The constituents in CCEO were characterized qualitatively by gas chromatography-mass spectrometry. Targets related to active ingredients were collected by PubChem and Swiss Target Prediction. Targets related to pain were screened by TTD and OMIM database, and compound-target network was established by Cytoscape software. Gene ontology (GO) function and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis of targets were carried out by DAVID database. Protein-protein interaction (PPI) network was established and analyzed by STRING database. Molecular docking method was used to verify the interaction between main components and relevant core targets. A total of 13 compounds were identified in CCEO, and 58 related targets were predicted. GO function enrichment analysis revealed that the selected targets were mainly involved in biological processes such as chemical synaptic transmission and molecular function such as neurotransmitter receptor activity; 24 signal pathways were screened by KEGG pathway enrichment analysis, including neuroactive ligand-receptor interaction, retrograde endocannabinoid signaling and calcium signaling pathway. Docking results showed that the main constituents had certain affinities with the key targets. The active ingredients in CCEO regulated multiple signaling pathways to ameliorate pain through AR, ACHE, ESR1, GABRG2, PTGS2 and PPARγ.
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    The main chemical constituents from Piper amalago: A review of its phytochemistry
    Zhaojun Zhang, Zhikang Duan, Xiaoxiao Huang
    Asian Journal of Traditional Medicines    2023, 18 (3): 98-115.  
    Abstract227)      PDF(pc) (1591KB)(144)      
    Piper amalago (P. amalago) is a traditional medicine in Brazil for the treatment of leishmanial. Owing to its rare occurrence and potent pharmacological activities, efforts have been devoted to the identification of its diverse constituents, especially terpenoids. Researchers have found that the major constituents of P. amalago were amides, monoterpenes, norisoprenoids, sesquiterpenes, aliphatic hydrocarbons and aromatic hydrocarbons. The amides show anxiolytic, anti-inflammatory, antileishmanial and antinociceptive activity. This review summarizes the research progress of the structural diversity and pharmacological activities of P. amalago.
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    Chemical constituents and biological activities of Artemisiae argyi
    Zhinan Leng, Yi’an Shi, Shuo Wang, Yunpeng Yang, Ji Wu, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (3): 116-136.  
    Abstract265)      PDF(pc) (1172KB)(119)      
    Artemisiae argyi (A. argyi) is a traditional medical plant, with medicinal and economic value. It has been used to treat diseases for more than 2000 years, and its application has been expanded in recent years with the in-depth research on the chemical composition and pharmacology. It is mainly used clinically for the treatment of “cold pain in the abdomen, cold clotting in the menstrual channels, cold infertility in the uterus, fetal movement, vomiting blood, epistaxis, pus and blood dysentery, and external treatment of itchy skin” and other symptoms. This paper reviews the research on the biological activity and chemical composition of A. argyi by scholars in recent decades.
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    Predicting ADME/Tox properties of hydroxytyrosol in the leaves of Olea europaea L.
    Suzhen Jiang, Xinghua Liu, Hongjian Yu, Shihong Li, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2023, 18 (2): 45-53.  
    Abstract145)      PDF(pc) (1823KB)(151)      
    In order to study the possibility of hydroxytyrosol (HT) as a drug, we used SwissADME system to predict ADME of HT and pkCSM system to predict Tox of HT. The results show that hydroxytyrosol meets the Lipinski’s five principles of drug-like properties. With strong efficacy and pharmacological activity, HT has high drug-likeness degree. With good bioavailability, it can be easily absorbed by the gastrointestinal tract, though not absorbed by skin. Hydroxytyrosol has not only a strong potency and pharmacological activity, but also no liver toxicity and skin allergy. Tox data predicts that it has mutagenic potential, which may be the result of overreduction.
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    Study on the pharmacological activities and chemical structures of Viburnum dilatatum
    Zhiheng Gao, Yufei Xi, Man Wang, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2023, 18 (2): 54-59.  
    Abstract109)      PDF(pc) (3063KB)(58)      
    Viburnum dilatatum (jiami in Chinese), belonging to the Caprifollaceae family, is widely distributed in Japan and China. Phytochemical investigations of Viburnum dilatatum (V. dilatatum) have resulted in the isolation of triterpenoids, phenolic glycosides essential oil, norisoprenoids, etc. Research results have shown that the chemical constituents of V. dilatatum possess various pharmacological activities, including antihyperglycemic, antioxidant activity and antiulcer effects. This study reviewed the chemical constituents and pharmacological activities of V. dilatatum to provide practical and useful information for further research and development of this plant.
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    Chemical compositions and biological activities of Flos lonicerae
    Yi’an Shi, Luming Pan, Luyan Yang, Jing Sun, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (2): 60-68.  
    Abstract110)      PDF(pc) (906KB)(62)      
    Flos lonicerae is the dry flower bud of Lonicera japonica Thunb, and it is a very important Chinese herbal medicine in China. In ancient times, it was widely used to treat the exopathogenic wind-heat, epidemic febrile diseases, sores, carbuncles and some infectious diseases. Modern pharmacological research has indicated that it has anti-inflammatory, anti-bacterial, anti-viral and anti-oxidation activities. This paper reviews the chemical compositions and biological activities of Flos lonicerae in order to provide reference for its application in clinical practice in the future.
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    Chemical constituents and pharmacological activities of Salvia miltiorrhiza
    Man Wang, Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang
    Asian Journal of Traditional Medicines    2023, 18 (2): 69-80.  
    Abstract125)      PDF(pc) (1305KB)(86)      
    Salvia miltiorrhiza Bunge (S. miltiorrhiza), a perennial plant of the genus Salvia, is widely used in traditional folklore medicine. Previous chemical research on this plant contains diterpenoid quinones, phenolic acids, polysaccharides and other compounds. The pharmacological investigation of S. miltiorrhiza has shown that it has various pharmacological activities, such as cardiovascular system protection, anti-inflammatory, anti-oxidant, anti-tumor, liver protection, and neuroprotection activities. This research tends to give an overview of the main chemical constituents and pharmacological effects of S. miltiorrhiza, aiming to reveal its potential value and provide reference for its further development.
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    Molecular mechanism study of Radix Pueraria for the treatment of glioma based on network pharmacology
    Li Ye, Jiaoyang Hou, Guodong Yao
    Asian Journal of Traditional Medicines    2023, 18 (1): 1-14.  
    Abstract156)      PDF(pc) (5717KB)(155)      
    Radix Pueraria (RP) has a long history of dual-use in medicine and food, and is well known as “Asian ginseng”. Recently, some studies about the effect of RP against glioma have been reported. However, little is elucidated about the molecular mechanism of interaction. This study used network pharmacology and molecular docking techniques to clarify the molecular mechanism of RP in the treatment of glioma. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was applied to screen potential active ingredients of RP and their targets. Targets for glioma were obtained from Genecards, OMIM, and Therapeutic Target Database (TTD). The topological analysis of cross-target and core target interaction was conducted using protein-protein interaction analysis (PPI). With the application of bioinformatics, GO and KEGG enrichment analyses were further carried out. Molecular docking was used then to validate the binding affinity between active components and key targets. This study successfully identified 6 potential active ingredients, namely beta-sitosterol, daidzein, formononetin, genistein, ononin, and puerarin. The hub targets were AKT1, TP53, VEGRA, EGFR, and MAPK3. These targets were mainly involved in biological processes, such as RNA polymerase II-specific DNA-binding transcription factor binding, and positive regulation of cell migration in the membrane raft, and were regulated by PI3K-Akt pathway. Further study showed that almost all the compounds had good binding abilities with above-mentioned targets. In short, this study systematically revealed the anti-glioma mechanism of RP to provide reference for the treatment of glioma.
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    A review of research on the chemical constituents and pharmacological effects of Elephantopus tomentosus L.
    Shuai Shen, Ming Bai, Shaojiang Song
    Asian Journal of Traditional Medicines    2023, 18 (1): 15-24.  
    Abstract131)      PDF(pc) (1942KB)(197)      
    Elephantopus tomentosus, belonging to the genus Elephantopus, is widely distributed in the coastal areas of southern China and tropical regions, used locally as traditional folk medicine. Previous phytochemistry studies on Elephantopus tomentosus led to the isolation of sesquiterpenoids, triterpenoids, flavonoids and other compounds. Research has shown that these compounds possess multiple biological activities, which have attracted great attention of researchers worldwide. This study reviews the chemical constituents and biological activities of the Elephantopus tomentosus in order to better explore and utilize Elephantopus tomentosus.
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    Investigation on the cognitive status and the infiltration path of Traditional Chinese Medicine among residents in Liaoning Province
    Shuling Wang, Zhaoxia Ren, Tingzhen Yao, Yalan He, Liang Liu
    Asian Journal of Traditional Medicines    2023, 18 (1): 25-37.  
    Abstract154)      PDF(pc) (941KB)(83)      
    To understand citizens’ awareness, trust and attitude towards Tradition Chinese medicine (TCM), to seek the best penetration path of TCM products and culture, to analyze their influencing factors, and to provide suggestions and countermeasures, a non-probabilistic judgment sampling method was used to conduct a survey among 459 people online with the help of Question naire Star and 434 valid questionnaires were collected. The survey shows that residents have a high degree of recognition and identification of Chinese medicine; citizens are rational when choosing TCM products, and the recognition of the emerging TCM culture infiltration path is low. Different social and demographic factors affect citizens’ awareness, trust and attitude towards TCM, as well as the choice of infiltration path (P < 0.05).
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    Mechanism of Ginkgo biloba L. leaf in the treatment of ischemic stroke based on network pharmacology, bioinformatics and molecular docking
    Hanxiao Shang, Fei Zhai, Ya Zeng, Yanjie Cao, Xiaohui Han, Rongwu Xiang, Jingyu Yang
    Asian Journal of Traditional Medicines    2022, 17 (6): 259-274.  
    Abstract229)      PDF(pc) (10854KB)(52)      
    Ginkgo biloba L. leaf (GBL) has been reported to protect against ischemic stroke (IS), one of the leading causes of death and long term disability worldwide, while there is a lack of systematic study on the exact mechanism. Here, network pharmacology and bioinformatics were used to predict the active components, important targets, and potential mechanisms of GBL in the treatment of IS. Active compounds of GBL were screened based on drug-like index and oral bioavailability, key target genes were screened based on network pharmacology and gene chip, downstream pathways for the regulation of key target genes were predicted based on gene set enrichment analysis, and the interaction between key targets and active compounds was verified based on molecular docking. The results showed that GBL played a protective role in cerebral ischemia with mainly 14 active compounds, such as isoquercitrin, luteolin-4’-glucoside, beta-sitosterol, campesterol, diosmetin, ginkgolide B, ginkgolide C, ginkgolide J, ginkgolide M, isogoycyrol, laricitrin, luteolin, sesamin, and stigmasterol. Further studies revealed that GBL played important role in immunomodulation and inflammation inhibition after cerebral ischemia by acting on its peripheral targets ARG1 and MMP9 to regulate Toll-like receptor, Chemokine and Notch signaling pathway. Meanwhile, GBL played important role in reducing neuroinflammation and blood-brain barrier damage after cerebral ischemia by acting on its central targets, CCL2, PTGS2, IL6, IL1B and MMP9 to regulate the Cytokine-cytokine receptor interaction, Jak-STAT, and Toll-like receptor signaling pathway. Additionally, molecular docking verified that the active compounds mentioned above could bind to ARG1, MMP9, CCL2, PTGS2, IL6, and IL1B. The present study shows the multicomponent, multitarget and multichannel pharmacological effects of GBL on cerebral ischemia and provides a new strategy for the treatment of IS.
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    Research review on the main chemical constituents and pharmacological effects of Chloranthus japonicus Sieb.
    Shuhe Jia, Rui Guo, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2022, 17 (6): 275-284.  
    Abstract123)      PDF(pc) (2165KB)(87)      
    Chloranthus japonicus Sieb., belonging to the Chloranthaceae family, is a perennial herb widely distributed in East Asia, including China, Japan and Korea. Previous phytochemical studies have revealed the presence of a variety of secondary metabolites, such as terpenoids, phenylpropanoids and phenolic derivatives. Among them, sesquiterpenes and dimers, as the main chemical constituents and research focus in this plant, have a variety of biological activities. This review mainly focuses on the research progress of  pharmacological activity of sesquiterpenes in this plant, which will lay the foundation for the development and utilization of its medicinal value in the future.
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    Research review on the main chemical constituents and pharmacological properties of Piper  flaviflorum
    Xiliang Li, Weiqi Zhang, Lili Lou
    Asian Journal of Traditional Medicines    2022, 17 (6): 285-293.  
    Abstract125)      PDF(pc) (1210KB)(120)      
    Piper flaviflorum (P. flaviflorum), belonging to the Piper genus of Piperaceae family, is widely distributed in south-central Yunnan.
    As a traditional medicine, P. flaviflorum has been used by the Dai people to treat dysmenorrhea and tinea. Phytochemical investigations of P. flaviflorum have resulted in the isolation of alkaloids, essential oils, glycosides and organic acid. Studies have shown that chemical constituents of P. flaviflorum have various pharmacological activities including anti-inflammatory, antifungal and anti-tumor effects. This paper reviewed the chemical constituents and pharmacological activities of P. flaviflorum to provide practical and useful information for further research and development of this plant.
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    A review: Chemical constituents and pharmacological activities of Solanum lyratum Thunb.
    Shuang Qiu, Qi Jia, Xiaoxiao Huang
    Asian Journal of Traditional Medicines    2022, 17 (6): 294-311.  
    Abstract133)      PDF(pc) (2451KB)(91)      
    Solanum lyratum Thunb. belonging to the family Solanaceae, is a common Chinese herbal medicine in folk. It has been used for the treatment of colds, fever, jaundice hepatitis, cholecystitis, cholelithiasis, nephritis, edema and cancer. Previous phytochemical studies on S. lyratum have led to the identification of many chemical constituents, including steroidal saponins, alkaloids, terpenoids, flavonoids, quinonoids, phenylpropanoids, organic acids and several other kinds of compounds, which showed diverse bioactivities, such as anticancer, anti-inflammatory and antioxidant activities. This paper summarized the primary chemical constituents and pharmacological effects of S. lyratum to provide reference for its further development and utilization.
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    Uncovering the mechanism of Sophora flavescens in the treatment of glioma based on network pharmacology
    Jiaqi Niu, Qian Li, Jinling Jiang, Guodong Yao
    Asian Journal of Traditional Medicines    2022, 17 (5): 193-211.  
    Abstract209)      PDF(pc) (5288KB)(194)      
    Glioma is a common primary intracranial tumor with high mortality and postoperative recurrence. Developing efficient therapies with lower toxicity is urgently needed. Sophora flavescens (SF) is a common Chinese medicine used to treat eczema, wet ulcers and itchy skin. Modern pharmacological studies have showed that SF has anti-glioma effects, but the mechanism of action remains unclear. This study aims to reveal the pharmacological mechanism of SF in treating glioma. The active components and related targets of SF were obtained from TCMSP. Genecard and Online Mendelian Inheritance in Man (OMIM) databases were used to explore the therapeutic targets for glioma. By making Venn diagram, we obtained 132 common targets of compounds and diseases. STRING databases and Cytoscape were used to construct diagrams of Protein-Protein Interaction (PPI) networks. Through the construction of PPI network, potential targets with degree value greater than the median were taken as core targets
    for further analysis. A total of 66 core targets were screened out. The degree values of TP53, HSP90AA1, MAPK1, and AKT1 were higher, indicating that these genes played important roles in this network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used to further discover the mechanism of active components in SF. Through enrichment analysis, it was found that the core targets were mainly enriched in PI3K/AKT signaling pathway, cell senescence related signaling pathway and IL-17 signaling pathway. In order to further explore the binding between active components and selected target, molecular docking was carried out. Finally, SwissADME was used to determine whether the compound could cross the blood-brain barrier. Based on network pharmacology, we speculated that matrine and formononetin in SF might inhibit PI3K/AKT signaling pathway and cellular senescence related signaling pathway by targeting AKT1, TP53,
    MAPK1 and other key targets. In summary, this study preliminarily explored the target and mode of action of SF in the treatment of glioma, laying the foundation for further research on its mechanism.
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    Progress on chemical constituents and pharmacological effects of Piper nigrum L.
    Ye Chang, Yuxi Wang, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2022, 17 (5): 212-225.  
    Abstract169)      PDF(pc) (1494KB)(230)      
    Piper nigrum L., belonging to Piper genus of the Piperaceae family, is a medicinal and edible plant. Studies have shown that there are many chemical constituents in this plant, including alkaloids, lignans, steroids and other compounds. In addition, some chemical components of P. nigrum have potential values to treat cancer, inflammation and other diseases. Research progress on the chemical constituents and pharmacological effects of P. nigrum was reviewed in this study to better explore its potential medicinal value.
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    The Genus Bletilla: A review of chemical constituents and pharmacological activities
    Wanyi Shi, Yuxi Wang, Xiaoxiao Huang
    Asian Journal of Traditional Medicines    2022, 17 (5): 226-243.  
    Abstract150)      PDF(pc) (1662KB)(155)      
    Bletilla striata is the traditional medicine widely used to treat a series of diseases such as bleeding, burns and tumor. The congeners have similar effect. This study reviewed the recent research progress on the chemical components and pharmacological activities of the genus Bletilla. The review summarized over 160 compounds isolated from the plants of genus Bletilla, including phenanthrenes, diphenanthrenes, bibenzyls, flavonoids and quinones. The plants of genus Bletilla have potent bioactivities, such as hemostatic activity, effect of promoting wound healing, antitumor activity and anti-inflammatory activity. Although a lot of compounds have been isolated from the genus Bletilla, pharmacological studies have been limited to anti-inflammatory and antibacterial activities.
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    Research review on the main chemical constituents and pharmacological activities of Viburnum awabuki
    Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2022, 17 (5): 244-252.  
    Abstract109)      PDF(pc) (1598KB)(161)      
    Viburnum awabuki (V. awabuki), belonging to the Viburnum genus, is an ideal tree species for landscaping. Phytochemical investigations of the V. awabuki have resulted in the isolation and identification of coumarins, lignans, sesquiterpenes, diterpenes and triterpenes. It has been reported that the extracts of V. awabuki have multiple pharmacological activities, including antitumor, anti-oxidant, plant growth inhibitory and neurite outgrowth-promoting activities. The research progress on the chemical constituents of V. awabuki and pharmacological activities were summarized in this review.
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    Uncovering the mechanism of Scutellariae Radix in the treatment of breast cancer based on network pharmacology
    Qian Li, Shaojiang Song
    Asian Journal of Traditional Medicines    2022, 17 (4): 143-160.  
    Abstract254)      PDF(pc) (3036KB)(172)      
    Breast cancer (BCa) is one of the most common malignant tumors that seriously affect women’s physical and mental health and even endanger their lives. Establishing a primary prevention program for BCa remains a challenge. Traditional Chinese medicine, Scutellariae Radix (SR), has been used to treat BCa while its pharmacological mechanism is still unclear. This study aims to reveal the pharmacological mechanism of SR in the treatment of BCa. Chemical constituents of SR were obtained and the targets of the compound were identified via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). GeneCards and DrugBank databases were used to collect BCa’s related target genes. Disease-compound common target protein interaction network was established by using the STRING database. The network diagrams of the active component action target and protein-protein interaction (PPI) networks were constructed by Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out to further explore the BCa mechanism and therapeutic effect of SR. As a result, 121 active compounds were obtained. The Venn diagram results showed that SR and BCa had 57 intersection targets, the more frequently targeted ones are TP53, JUN, CCND1, AKT1, which could affect biological processes such as response to steroid hormone and positive regulation of cell death. KEGG analysis revealed that these targets were related to IL-17 signaling pathway, p53 signaling pathway and PI3K-Akt signaling pathway. In conclusion, this study preliminarily verified the target and mode of action of SR in the treatment of BCa, laying a foundation for further research on its mechanism.
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    Research progress on the lignans from the genus Schisandra and their biological activities
    Luqi Liu, Xueqing Zhang, Yongcheng Yang, Sanpeng Fan, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2022, 17 (4): 161-180.  
    Abstract154)      PDF(pc) (2695KB)(198)      
    The plants of the genus Schisandra belong to the Schisandraceae family. As one of the main active components of genus Schisandra, lignans have rich biological activities, including anti-inflammatory, anti-tumor, anti-HIV and PAF antagonism. This article summarizes and classifies the types and activities of lignans isolated from the genus Schisandra in the past ten years.
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    Volatile oil from Litsea lancilimba Merr.: a review of its chemical structure and biological activity
    Yijie Zhang, Ming Bai, Weiyu Zhou, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2022, 17 (4): 181-185.  
    Abstract108)      PDF(pc) (900KB)(98)      
    Litsea lancilimba Merr. is a Cinnamomum plant of Lauraceae. Phytochemical investigations of the Litsea lancilimba Merr. have resulted in the isolation of Volatile oil, flavonoid glycosides, tannins, alkaloids, lignans, organic acids and so on. Studies have showed that volatile oil is the main chemical component. Recent trials have demonstrated the efficacy of Litsea lancilimba Merr. in strengthening the function of stomach. The fruits have also been demonstrated to possess anti-inflammatory and bacteriostatic activities. This review deals mainly with the chemical structure and biological activities of Litsea lancilimba Merr. oil.
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    A review: Panax ginseng diseases and the control techniques
    Mo Yao, Liwen Chen, Luming Pan, Haonan Yu, Yuhang Liu, Miao Wang, Yu Chen
    Asian Journal of Traditional Medicines    2022, 17 (4): 186-191.  
    Abstract189)      PDF(pc) (789KB)(179)      
    Panax ginseng (P. ginseng) is a famous traditional medical plant, with both the medical and economic value. In China, the cultivation of P. ginseng is a major agricultural activity. However, the yield and quality have declined in recent years due to various diseases. This review summarized the common diseases of P. ginseng and the controlling techniques, aiming to enhance the cultivation of P. ginseng and ensure the sustainable development of P. ginseng industry.
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    Research review on the main chemical constituents and pharmacological effects of Tripterygium hypoglaucum (Levl.) Hutch.
    Yunfei Ai, Shuhui Dong, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2022, 17 (3): 94-107.  
    Abstract200)      PDF(pc) (2350KB)(268)      
    Tripterygium hypoglaucum (Levl.) Hutch. (THH), which belongs to Tripterygium genus of Celastraceae family, is widely used as the common Chinese herbal medicine. It has been reported that the chemical constituents of T. hypoglaucum include monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids, sesquiterpene alkaloids, flavonoids, anthraquinone derivatives, et al. These compounds showed a wide range of bioactivities, such as anti-inflammatory, anti-cancer, immunosuppressive, anti-HIV, anti-fertility and insecticidal activities. In this paper, we summarized the chemical
    constituents and pharmacological activities of T. hypoglaucum to provide a reference for its further research and developement.
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    Chemical composition and pharmacological activities of Polygonum cuspidatum
    Yi’an Shi, Luming Pan, Jiayi Bi, Xuefei Yang, Jing Sun, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2022, 17 (3): 108-115.  
    Abstract217)      PDF(pc) (902KB)(260)      
    Polygonum cuspidatum is a traditional Chinese medicine, and its medicinal part is dry rhizome. It is mainly used to treat damp heat jaundice, burns, carbuncle, ulcer poisoning, amenorrhea, and snake bite. Recent studies have found that P. cuspidatum also contains active ingredients against coronaviruses. This paper reviews the chemical constituents and pharmacological activities of P. cuspidatum, so as to provide a scientific basis for the development and utilization of P. cuspidatum resources in the future.
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    Research progress on the triterpenoids from the genus Schisandra and their biological activities
    Yongcheng Yang, Luqi Liu, Zijun Tang, Min Chen, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2022, 17 (3): 116-136.  
    Abstract220)      PDF(pc) (1520KB)(347)      
    The plants of the genus Schisandra of the Schisandraceae family include the genus Schisandra and the genus Kadsura. In recent years, many kinds of triterpenoids have been isolated from the plants of genus Schisandra. Triterpenoids have attracted the attention of phytochemists and pharmacologists because they have novel skeletons and good anti-HIV, immunosuppressive and anti-tumor activities. This study provides an overview of the triterpenoids from the genus Schisandra and their biological activities.
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    Network pharmacology-based virtual screening of the active volatile oil ingredients of Litsea lancilimba Merr. and their potential targets for treating liver cancer
    Yijie Zhang, Ming Bai, Weiyu Zhou, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2022, 17 (2): 47-50.  
    Abstract209)      PDF(pc) (1267KB)(307)      
    Liver cancer remains the dominant cause of cancer-related death, despite the advent of targeted therapies and immunotherapies. Therefore, there is an urgent need to explore novel chemotherapeutic agents and effective strategies against the cancer. There are a lot of monoterpenes and sesquiterpenoids in L. lancilimba. It has been reported that monoterpenes and sesquiterpenoids have certain anti-tumor effects. Literature investigation has also shown that Litsea lancilimba Merr. has antibacterial and antiviral effects. In this experiment, we used network pharmacology to screen the active compounds from L. lancilimba and their potential targets for treating liver cancer. Four active volatile oil ingredients and four potential targets have been identified. Our results provide the lead compound from L. lancilimba in the treatment of liver cancerv.
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    Molecular mechanism of Salvia miltiorrhiza Bunge and Carthamus tinctorius L. in the treatment of myocardial ischemia based on network pharmacology: a comparative study
    Ronghong Liu, Yanping Wang, Wenjing Li, Bo Hong
    Asian Journal of Traditional Medicines    2022, 17 (2): 51-64.  
    Abstract0)      PDF(pc) (7284KB)(0)      
    Based on network pharmacology and molecular docking technology, the similarities and differences of anti-myocardial ischemia mechanism between Salvia miltiorrhiza Bunge (SM) and Carthamus tinctorius L. (CT) were studied. Firstly, based on the traditional Chinese medicine systems pharmacology (TCMSP), the related compounds of SM and CT were obtained, and the potential targets of these compounds were collected by the target fishing method. Genecards database was used to obtain targets related to myocardial ischemia. The cross targets of CT, SM, and myocardial ischemia were then selected, and the protein-protein interaction (PPI) network was constructed based on the STRING database. The cross targets were imported into the Metascape database for Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Cytoscape software was used to build the topological network diagram of the drug-compound-target path. Finally, the binding ability of the active ingredient and the key target was verified by molecular docking. 65 active ingredients and 38 potential targets were screened from SM, and 22 active ingredients and 58 potential targets were excavated from CT. Important targets common to SM and CT were TNF, IL6, VEGFA, AKT1, etc. The common enrichment pathways involved are fluid shear stress and atherosclerosis, IL-17 signaling pathway, pathways in cancer, and toxoplasmosis. The findings suggested that the two traditional Chinese medicines exerted the effect of myocardial ischemia through the characteristics of multiple targets, multiple pathways, and multiple compounds.
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