亚洲传统医药
亚洲传统医药

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›› 2012, Vol. 7 ›› Issue (1): 39-43.

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CNS depressent activity of different extracts of Tecoma stans flowers

  

  • 收稿日期:2011-10-25 修回日期:2012-11-26 出版日期:2012-02-20 发布日期:2012-02-20

CNS depressent activity of different extracts of Tecoma stans flowers

Kameshwaran Sugavanam 1*; Suresh Velayutham 1; Arunachalam Ganesan 2   

  1. 1. Department of Pharmacology, JKK Munirajah Medical Research Foundation and College of Pharmacy, B. Komarapalayam, Namakkal, Tamilnadu 638183, India2. Professor & Principal, PGP College of Pharmaceutical Science & Research Institute, Namakkal, Tamilnadu 637207, India
  • Received:2011-10-25 Revised:2012-11-26 Online:2012-02-20 Published:2012-02-20
  • Contact: Kameshwaran Sugavanam

Abstract: Tecoma stans is popularly known as Yellow bell and is, an ornamental plant widely distributed throughout India. The objective of the present study was to evaluate the CNS depressant potential of different extracts of Tecoma stans flowers. The flowers extracted successively with solvents of increasing polarity, namely, chloroform, methanol and water. Albino mice (18-25 g) of both sexes were used in these experiments and the CNS depressant activity was evaluated by measuring the pentobarbitone- induced sleeping time and locomotor activity using an actophotometer. The methanolic extract of Tecoma stans flowers (400 mg/kg) exhibited the highest activity, significantly (P<0.01) reducing the time to onset and sleep duration induced by pentobarbitone, and the extract also reduced locomotor activity by 68.36%. The water and chloroform extracts also exhibited dose- dependent CNS depressant activity. These results indicate that different extracts of Tecoma stans flowers exhibit CNS depressant activity.

Key words: Tecoma stans, pentobarbitone, actophotometer, methanolic extract

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