亚洲传统医药
亚洲传统医药

快速检索 年期检索

亚洲传统医药

• Regular Article • 上一篇    

Antibacterial Activity Test of Coptis chinensis Alkaloids Combined with Moxifloxacin

Feng Xu 1, Lijie Zhao 2, Fan Che 1, Siyu Hu 1, Yu Chen 1, Huasong Liu 1, Wei Xu 1*, Feng Qiu 3*   

  1. 1 School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Teaching and Research Section of Health, Unit 95979 of Shenyang Military Area, Shenyang 110045, China; 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 收稿日期:2015-11-13 修回日期:2016-02-18 出版日期:2016-08-20 发布日期:2016-02-18

Antibacterial Activity Test of Coptis chinensis Alkaloids Combined with Moxifloxacin

Feng Xu 1, Lijie Zhao 2, Fan Che 1, Siyu Hu 1, Yu Chen 1, Huasong Liu 1, Wei Xu 1*, Feng Qiu 3*   

  1. 1 School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Teaching and Research Section of Health, Unit 95979 of Shenyang Military Area, Shenyang 110045, China; 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received:2015-11-13 Revised:2016-02-18 Online:2016-08-20 Published:2016-02-18
  • Contact: Feng Qiu: Address: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Tel: +86-24-23986463; E-mail: fengqiu2000@tom.com. Wei Xu: Address: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China; Tel: +86-24-23986702; E-mail: shxuwei8720@163.com.

PDF

351

摘要： Coptis chinensis alkaloids are used as antimicrobial agents for a long time. This study was to investigate the potential antibacterial activity of alkaloids combinated with moxifloxacin. It was found that Coptis chinensis alkaloids combined with moxifloxacin had obviously synergistic bactericidal efficacy. The fractionary inhibitory concentration index (FICI) to Staphylococcus aureus [CMCC (B) 26003], Escherichia coli [CMCC (B) 44102] and Bacillus subtilis [CMCC (B) 63501] were 0.625, 0.75 and 0.05625, respectively. These results could lay the foundation of cutting down the wide use of chemical antimicrobials in the future.

关键词: Coptis chinensis alkaloids, moxifloxacin, checkerboard method

Abstract: Coptis chinensis alkaloids are used as antimicrobial agents for a long time. This study was to investigate the potential antibacterial activity of alkaloids combinated with moxifloxacin. It was found that Coptis chinensis alkaloids combined with moxifloxacin had obviously synergistic bactericidal efficacy. The fractionary inhibitory concentration index (FICI) to Staphylococcus aureus [CMCC (B) 26003], Escherichia coli [CMCC (B) 44102] and Bacillus subtilis [CMCC (B) 63501] were 0.625, 0.75 and 0.05625, respectively. These results could lay the foundation of cutting down the wide use of chemical antimicrobials in the future.

Key words: Coptis chinensis alkaloids, moxifloxacin, checkerboard method

版权所有 © 2019 《亚洲传统医药》

本系统由北京玛格泰克科技发展有限公司设计开发