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Protective effect of total glycoside from Ligustri Lucidi Fructus against concanavalin A-induced liver injury in mice

Nianyun Yang*, Jianming Guo, Li Yu   

  1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
  • 收稿日期:2016-04-16 修回日期:2016-10-26 出版日期:2016-12-20 发布日期:2016-10-26

Protective effect of total glycoside from Ligustri Lucidi Fructus against concanavalin A-induced liver injury in mice

Nianyun Yang*, Jianming Guo, Li Yu   

  1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
  • Received:2016-04-16 Revised:2016-10-26 Online:2016-12-20 Published:2016-10-26
  • Contact: Nianyun Yang*,College of Pharmacy, Nanjing University of Chinese Medicine, No. 138, Xianlin Road, Nanjing 210023, China; Tel: +86-25-85811074; E-mail: nianyunyang@163.com

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摘要： The protective effects of total glycoside extract (TGE) from the fruits of Ligustrum lucidum on concanavalin A (Con A)-induced liver injury in mice were investigated. Con A injection into the tail vein caused hepatitis mice model and TGE was meanwhile intervened, while the mice in control group were fed normal diet. At the end of experiments, all the mice were sacrificed to analyze serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels. Pathological changes of hepatic tissues were observed under microscope. Compared to model group, serum ALT, AST, TNF-α and IL-6 levels exhibited an obvious reduction in TGE intervened mice (P<0.05). TGE has a significant preventive effect on Con A-induced hepatitis in mice, which can inhibit pro-inflammatory cytokines, relieve the peroxidation injury and improve liver function.

关键词: Ligustrum lucidum, Concanavalin A-induced hepatitis, protective effect

Abstract: The protective effects of total glycoside extract (TGE) from the fruits of Ligustrum lucidum on concanavalin A (Con A)-induced liver injury in mice were investigated. Con A injection into the tail vein caused hepatitis mice model and TGE was meanwhile intervened, while the mice in control group were fed normal diet. At the end of experiments, all the mice were sacrificed to analyze serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels. Pathological changes of hepatic tissues were observed under microscope. Compared to model group, serum ALT, AST, TNF-α and IL-6 levels exhibited an obvious reduction in TGE intervened mice (P<0.05). TGE has a significant preventive effect on Con A-induced hepatitis in mice, which can inhibit pro-inflammatory cytokines, relieve the peroxidation injury and improve liver function.

Key words: Ligustrum lucidum, Concanavalin A-induced hepatitis, protective effect

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