Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity

亚洲传统医药

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Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity

Linyan Sun, Guoxiang Sun*, Jing Zhang

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

收稿日期:2016-09-21 修回日期:2017-01-06 出版日期:2017-04-20 发布日期:2017-01-06

Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity

Linyan Sun, Guoxiang Sun*, Jing Zhang

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2016-09-21 Revised:2017-01-06 Online:2017-04-20 Published:2017-01-06
Contact: Shenyang Pharmaceutical University, 85 Hongliu Road, Shiqiaozi Town, Benxi, Liaoning Province, 117004, China; Fax: +86-024-2398628; E-mail: gxswmwys@163.com.

摘要/Abstract

摘要： HPLC coupled with diode array detector (DAD) was adopted to monitor the quality consistency of Compound Liangmianzhen tablets (LMZT). An overall integrated fingerprint assessment strategy was set up to reveal the whole information at different wavelengths, and 220 nm HPLC fingerprints as well as single maker component were determined, in combination of antioxidant activity detected by 1,1-diphenyl-2-picrylhydrazyl (DPPH). The systematic quantitative fingerprint method (SQFM) was applied in the fingerprint assessments and we did mathematical separation for overlapping peaks which can’t be separated under chromatographic conditions before evaluation. The samples were all quantified and 11 kinds of components had antioxidant activity.

关键词: antioxidant activity, Compound Liangmianzhen tablets, HPLC fingerprints, partial least squares regression, systematic quantitative fingerprint method

Abstract: HPLC coupled with diode array detector (DAD) was adopted to monitor the quality consistency of Compound Liangmianzhen tablets (LMZT). An overall integrated fingerprint assessment strategy was set up to reveal the whole information at different wavelengths, and 220 nm HPLC fingerprints as well as single maker component were determined, in combination of antioxidant activity detected by 1,1-diphenyl-2-picrylhydrazyl (DPPH). The systematic quantitative fingerprint method (SQFM) was applied in the fingerprint assessments and we did mathematical separation for overlapping peaks which can’t be separated under chromatographic conditions before evaluation. The samples were all quantified and 11 kinds of components had antioxidant activity.

Key words: antioxidant activity, Compound Liangmianzhen tablets, HPLC fingerprints, partial least squares regression, systematic quantitative fingerprint method

Linyan Sun, Guoxiang Sun, Jing Zhang. Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity[J]. 亚洲传统医药.

Linyan Sun, Guoxiang Sun, Jing Zhang. Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity[J]. Asina Journal Of Traditional Medicines.

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Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity

Evaluation of the quality consistency of Compound Liangmianzhen tablets using HPLC fingerprints for antioxidant activity

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