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Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang*
Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang*
摘要: Six compounds were isolated from the water extractive of Safflower (Carthamus tinctorius L.). Their structures were elucidated via sufficient analyses of the spectroscopic data, including 1 H NMR, 13C NMR and HRESIMS. All the isolated compounds were tested for inhibitory activity against tyrosinase to inspect their effect on melanogenesis. At the concentration of 100 μmol/ml, compound 1 and 4-6 possessed more potency, with the inhibition rate at 67.51%, 84.91%, 72.16%, 92.37%, respectively, compared to arbutin (54.34%). Compound 3 exhibited moderate inhibitory activity with the inhibition rate at 48.65%. Molecular docking was performed to investigate mechanism of inhibition.