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Oleanolic acid saponins from Monoammonium glycyrrhinate and their NO inhibition activity

Qiang Ren, Ming Bai, Qin Li, Guodong Yao, Xiaoxiao Huang*, Shaojiang Song*   

  1. Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 收稿日期:2017-01-20 修回日期:2017-04-21 出版日期:2017-10-20 发布日期:2017-04-21

Oleanolic acid saponins from Monoammonium glycyrrhinate and their NO inhibition activity

Qiang Ren, Ming Bai, Qin Li, Guodong Yao, Xiaoxiao Huang*, Shaojiang Song*   

  1. Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received:2017-01-20 Revised:2017-04-21 Online:2017-10-20 Published:2017-04-21
  • Contact: Xiaoxiao Huang*, Shaojiang Song* , Shenyang Pharmaceutical University, 103 wenhua Rd., shenyang 110016, People’s Republic of China; E-mail: xiaoxiao270@163. com (X.-X. Huang), songsj99@163.com(S.-J. Song); Tel.: 15840267586(X.-X. Huang), 13998392228(S.-J. Song); Fax: +86 -24-23986510

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摘要： Six oleanolic acid saponins were isolated from Monoammonium glycyrrhinate (MAG). Their structures were elucidated via spectroscopic data analyses, including 13C NMR and HRESIMS. The assay concerning the inhibition of NO inhibition induced by lipopolysaccharide in RAW 264.7 cells was conducted to evaluate their anti-inflammatory activity of the isolated triterpenoid saponins. The results revealed that compound 4 exhibited weak inhibitory activity on the production of NO with the inhibition rate 12.04% at 100 μM compared with the positive control drug, minocycline, the inhibition rate of which was 35.39% at 100 μM.

关键词: Licorice, Monoammonium glycyrrhinate, oleanolic acid saponins, NO inhibition, anti-inflammatory

Abstract: Six oleanolic acid saponins were isolated from Monoammonium glycyrrhinate (MAG). Their structures were elucidated via spectroscopic data analyses, including 13C NMR and HRESIMS. The assay concerning the inhibition of NO inhibition induced by lipopolysaccharide in RAW 264.7 cells was conducted to evaluate their anti-inflammatory activity of the isolated triterpenoid saponins. The results revealed that compound 4 exhibited weak inhibitory activity on the production of NO with the inhibition rate 12.04% at 100 μM compared with the positive control drug, minocycline, the inhibition rate of which was 35.39% at 100 μM.

Key words: Licorice, Monoammonium glycyrrhinate, oleanolic acid saponins, NO inhibition, anti-inflammatory

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