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Phenolic compounds from Pithecellobium clypearia with tyrosinase inhibitory activity

Han Zhang, Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang*   

  1. Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China
  • 收稿日期:2017-11-16 修回日期:2017-12-30 出版日期:2018-04-20 发布日期:2017-12-30

Phenolic compounds from Pithecellobium clypearia with tyrosinase inhibitory activity

Han Zhang, Zhiyang Yan, Yuxi Wang, Xiaoxiao Huang*   

  1. Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China
  • Received:2017-11-16 Revised:2017-12-30 Online:2018-04-20 Published:2017-12-30
  • Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986510; E-mail: xiaoxiao270@163.com.

摘要: A series of phenolic acids from Pithecellobium clypearia have been isolated. Their stereochemical structures were determined by comprehensive spectroscopic data analyses. The tyrosinase inhibitory activity of all compounds was tested to investigate the effects on their melanogenesis. The result showed that compounds 1 and 5 exhibited higher tyrosinase inhibitory activities (inhibitory ratios at 92.15%, 93.57%, respectively) than the reference compound, arbutin (57.35%). Docking experiments were carried out in order to study the interactions between these compounds and mushroom tyrosinase.

关键词: Pithecellobium clypearia, tyrosinase inhibition, molecular docking

Abstract: A series of phenolic acids from Pithecellobium clypearia have been isolated. Their stereochemical structures were determined by comprehensive spectroscopic data analyses. The tyrosinase inhibitory activity of all compounds was tested to investigate the effects on their melanogenesis. The result showed that compounds 1 and 5 exhibited higher tyrosinase inhibitory activities (inhibitory ratios at 92.15%, 93.57%, respectively) than the reference compound, arbutin (57.35%). Docking experiments were carried out in order to study the interactions between these compounds and mushroom tyrosinase.

Key words: Pithecellobium clypearia, tyrosinase inhibition, molecular docking