Screening of potential active compounds in Eurycoma longifolia
against hepatic carcinoma by Network pharmacology

亚洲传统医药

• Regular Article • 下一篇

Screening of potential active compounds in Eurycoma longifolia against hepatic carcinoma by Network pharmacology

Chunxin Zou 1, Wenyu Zhao 1, Zhiyang Yan 1, Xiaoxiao Huang 1,2*, Shaojiang Song 1, Xiaobo Wang 1,2*

1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Chinese People’s Liberation Army 210 Hospital, Dalian 116021, China

收稿日期:2017-11-16 修回日期:2018-01-11 出版日期:2018-06-20 发布日期:2018-01-11

Screening of potential active compounds in Eurycoma longifolia against hepatic carcinoma by Network pharmacology

Chunxin Zou 1, Wenyu Zhao 1, Zhiyang Yan 1, Xiaoxiao Huang 1,2*, Shaojiang Song 1, Xiaobo Wang 1,2*

1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Chinese People’s Liberation Army 210 Hospital, Dalian 116021, China

Received:2017-11-16 Revised:2018-01-11 Online:2018-06-20 Published:2018-01-11
Contact: School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University, 103 Wenhua Rd.,Shenyang 110016, China; Tel.:+86-24-23986486(Xiaoxiao Huang); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang), wxbbenson0653@sina. com (Xiaobo Wang).

摘要/Abstract

摘要： Eurycoma longifolia as one of the most well-known folk medicines, belongs to Eurycoma genus of Simaroubaceae family. Pharmacology researches reported that E. longifolia has been widely used for its anticancer, antimalarial, aphrodisiac, antiinflammatory, and antibacterial activities. However, its system-level researches of drug-target associations is not enough. Here we employed molecular docking and network pharmacology methods to predict the effective compositions and its potential target proteins. Eight compounds in E. longifolia belonging to squalene derivatives, biphenyl neolignans and alkaloids were predicted to have potential activity for liver-cancer target proteins. Meanwhile, we analyzed the interaction mode of these active components with nuclear receptor coactivator 2 (3up3), which may be the pivotal target on inhibiting liver cancer. This article is presented to explore the active ingredients of E. longifolia and provide crucial material for the further research and development of the plant.

关键词: Eurycoma longifolia, network pharmacology, active ingredients, potential target

Abstract: Eurycoma longifolia as one of the most well-known folk medicines, belongs to Eurycoma genus of Simaroubaceae family. Pharmacology researches reported that E. longifolia has been widely used for its anticancer, antimalarial, aphrodisiac, antiinflammatory, and antibacterial activities. However, its system-level researches of drug-target associations is not enough. Here we employed molecular docking and network pharmacology methods to predict the effective compositions and its potential target proteins. Eight compounds in E. longifolia belonging to squalene derivatives, biphenyl neolignans and alkaloids were predicted to have potential activity for liver-cancer target proteins. Meanwhile, we analyzed the interaction mode of these active components with nuclear receptor coactivator 2 (3up3), which may be the pivotal target on inhibiting liver cancer. This article is presented to explore the active ingredients of E. longifolia and provide crucial material for the further research and development of the plant.

Key words: Eurycoma longifolia, network pharmacology, active ingredients, potential target

Chunxin Zou, Wenyu Zhao, Zhiyang Yan, Xiaoxiao Huang, Shaojiang Song, Xiaobo Wan. Screening of potential active compounds in Eurycoma longifolia against hepatic carcinoma by Network pharmacology[J]. 亚洲传统医药.

Chunxin Zou, Wenyu Zhao, Zhiyang Yan, Xiaoxiao Huang, Shaojiang Song, Xiaobo Wang. Screening of potential active compounds in Eurycoma longifolia against hepatic carcinoma by Network pharmacology[J]. Asina Journal Of Traditional Medicines.

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Screening of potential active compounds in Eurycoma longifolia against hepatic carcinoma by Network pharmacology

Screening of potential active compounds in Eurycoma longifolia against hepatic carcinoma by Network pharmacology

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