Fast quantified counter chemicals of Dan Shen by
fingerprints and correlated with antioxidating profiles

亚洲传统医药

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Fast quantified counter chemicals of Dan Shen by fingerprints and correlated with antioxidating profiles

Yujing Zhang, Guoxiang Sun*

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

收稿日期:2015-12-21 修回日期:2016-02-18 出版日期:2016-04-20 发布日期:2016-02-18

Fast quantified counter chemicals of Dan Shen by fingerprints and correlated with antioxidating profiles

Yujing Zhang, Guoxiang Sun*

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2015-12-21 Revised:2016-02-18 Online:2016-04-20 Published:2016-02-18
Contact: Guoxiang Sun*, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China; Tel.: +86-24-23986286; Email: gxswmwys@163.com

摘要/Abstract

摘要： A combination method of fingerprint analysis and antioxidant analysis was developed and validated in order to evaluate the quality consistency of traditional Chinese medicine (TCM) / Dan Shen (DS). In the fingerprint analysis nine major chromatographic peaks were detected in DS sample, which were identified as: Protocatechuic acid (PHA), Protocatechualdehyde (PHD), Rosmarinic acid (RMA), Caffeic acid (CFA), Tanshinone IIA (T2A), Salvianolic acid B (SAB), Lithospermic acid (LSA), Propanoic acid (PPA), Salvianolic acid A (SAA). In the antioxidant analysis, IC50 and antioxidant capacity of the individual markers was successfully measured and predicted coupled with partial least squares regression (PLSR). This study indicated that the antioxidant activity, and the associated fingerprint analysis based on systematically quantified fingerprint method (SQFM) could assess the quality of TCM efficiently and credibly.

关键词: Dan Shen, HPLC fingerprint, antioxidant activity, quality control, SQFM

Abstract: A combination method of fingerprint analysis and antioxidant analysis was developed and validated in order to evaluate the quality consistency of traditional Chinese medicine (TCM) / Dan Shen (DS). In the fingerprint analysis nine major chromatographic peaks were detected in DS sample, which were identified as: Protocatechuic acid (PHA), Protocatechualdehyde (PHD), Rosmarinic acid (RMA), Caffeic acid (CFA), Tanshinone IIA (T2A), Salvianolic acid B (SAB), Lithospermic acid (LSA), Propanoic acid (PPA), Salvianolic acid A (SAA). In the antioxidant analysis, IC50 and antioxidant capacity of the individual markers was successfully measured and predicted coupled with partial least squares regression (PLSR). This study indicated that the antioxidant activity, and the associated fingerprint analysis based on systematically quantified fingerprint method (SQFM) could assess the quality of TCM efficiently and credibly.

Key words: Dan Shen, HPLC fingerprint, antioxidant activity, quality control, SQFM

. Fast quantified counter chemicals of Dan Shen by fingerprints and correlated with antioxidating profiles[J]. 亚洲传统医药.

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亚洲传统医药

Fast quantified counter chemicals of Dan Shen by fingerprints and correlated with antioxidating profiles

Fast quantified counter chemicals of Dan Shen by fingerprints and correlated with antioxidating profiles

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