Virtual Screening of Active Compounds and Potential
Targets from Harrisonia perforata (Blanco) Merr. against
Liver Cancer Based on Network Pharmacology

亚洲传统医药

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Virtual Screening of Active Compounds and Potential Targets from Harrisonia perforata (Blanco) Merr. against Liver Cancer Based on Network Pharmacology

Shifang Li, Ming Bai, Xiaoxiao Huang 1,2*, Shaojiang Song 1*

1 Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China

收稿日期:2017-12-05 修回日期:2018-03-18 出版日期:2018-10-20 发布日期:2018-11-13

Virtual Screening of Active Compounds and Potential Targets from Harrisonia perforata (Blanco) Merr. against Liver Cancer Based on Network Pharmacology

Shifang Li, Ming Bai, Xiaoxiao Huang 1,2*, Shaojiang Song 1*

1 Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China

Received:2017-12-05 Revised:2018-03-18 Online:2018-10-20 Published:2018-11-13
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986486 (Xiaoxiao Huang); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang), songsj99@163.com (Shaojiang Song).

摘要/Abstract

摘要： Traditional Chinese Medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets. Harrisonia perforata, belonging to Simarubaceae family, was proved to be effective to cure cancer, but the action mechanism is unclear. In this paper, we utilized molecular docking and network analysis to find out the active ingredients of H. perforata and the potential target proteins involved in liver cancer, which is meaningful for the further research of liver cancer.

关键词: network pharmacology, liver cancer, Harrisonia perforata

Abstract: Traditional Chinese Medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets. Harrisonia perforata, belonging to Simarubaceae family, was proved to be effective to cure cancer, but the action mechanism is unclear. In this paper, we utilized molecular docking and network analysis to find out the active ingredients of H. perforata and the potential target proteins involved in liver cancer, which is meaningful for the further research of liver cancer.

Key words: network pharmacology, liver cancer, Harrisonia perforata

Shifang Li, Ming Bai, Xiaoxiao Huang, Shaojiang Song. Virtual Screening of Active Compounds and Potential Targets from Harrisonia perforata (Blanco) Merr. against Liver Cancer Based on Network Pharmacology[J]. 亚洲传统医药.

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亚洲传统医药

Virtual Screening of Active Compounds and Potential Targets from Harrisonia perforata (Blanco) Merr. against Liver Cancer Based on Network Pharmacology

Virtual Screening of Active Compounds and Potential Targets from Harrisonia perforata (Blanco) Merr. against Liver Cancer Based on Network Pharmacology

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