Network pharmacology-based virtual screening of the
active ingredients and potential targets from amide
alkaloids of Piper genus against Alzheimer’s disease

亚洲传统医药

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Network pharmacology-based virtual screening of the active ingredients and potential targets from amide alkaloids of Piper genus against Alzheimer’s disease

Weiyu Zhou, Ming Bai, Xiaoxiao Huang*, Shaojiang Song*

Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China

收稿日期:2017-11-27 修回日期:2018-03-18 出版日期:2018-10-20 发布日期:2018-11-13

Network pharmacology-based virtual screening of the active ingredients and potential targets from amide alkaloids of Piper genus against Alzheimer’s disease

Weiyu Zhou, Ming Bai, Xiaoxiao Huang*, Shaojiang Song*

Department of Natural Products Chemistry, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China

Received:2017-11-27 Revised:2018-03-18 Online:2018-10-20 Published:2018-11-13
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986510 (Xiaoxiao Huang); E-mail: xiaoxiao270@163.com (Xiaoxiao Huang); School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986510 (Shaojiang Song); E-mail: songsj99@163.com (Shaojiang Song)

摘要/Abstract

摘要： Alzheimer’s disease (AD) is a genetically complex neurodegenerative disease and its pathological mechanism has not been fully discovered. In the current study, we have examined the medicinal effect of amide alkaloids of the Piper genus in the treatment of AD using network pharmacology. High-confidence level networks consisting of compound-protein target and protein targetpathway association were developed and the potential active amide alkaloids of the Piper genus, the potential target proteins and the key pathways were predicted by network pharmacology models. Overall, this approach provided a novel strategy to explore the role of amide alkaloids of the Piper genus in the treatment of AD from a holistic perspective.

关键词: Alzheimer’s disease, amide alkaloids, Piper genus, network pharmacology

Abstract: Alzheimer’s disease (AD) is a genetically complex neurodegenerative disease and its pathological mechanism has not been fully discovered. In the current study, we have examined the medicinal effect of amide alkaloids of the Piper genus in the treatment of AD using network pharmacology. High-confidence level networks consisting of compound-protein target and protein targetpathway association were developed and the potential active amide alkaloids of the Piper genus, the potential target proteins and the key pathways were predicted by network pharmacology models. Overall, this approach provided a novel strategy to explore the role of amide alkaloids of the Piper genus in the treatment of AD from a holistic perspective.

Key words: Alzheimer’s disease, amide alkaloids, Piper genus, network pharmacology

Weiyu Zhou, Ming Bai, Xiaoxiao Huang, Shaojiang Song. Network pharmacology-based virtual screening of the active ingredients and potential targets from amide alkaloids of Piper genus against Alzheimer’s disease[J]. 亚洲传统医药.

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亚洲传统医药

Network pharmacology-based virtual screening of the active ingredients and potential targets from amide alkaloids of Piper genus against Alzheimer’s disease

Network pharmacology-based virtual screening of the active ingredients and potential targets from amide alkaloids of Piper genus against Alzheimer’s disease

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