亚洲传统医药
亚洲传统医药

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亚洲传统医药 ›› 2021, Vol. 16 ›› Issue (1): 32-52.

• Review • 上一篇    下一篇

SARS-CoV-2: structure, host, virus source and pathogenesis

Mingxue Li 1, Yueying Yang 1,Yang Liu 1, Mengzhu Zheng 2, Dejuan Sun 1*, Hua Li 1,2*, Lixia Chen 1*   

  1. 1. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • 收稿日期:2020-08-09 接受日期:2020-12-21 出版日期:2021-02-20 发布日期:2021-03-02

SARS-CoV-2: structure, host, virus source and pathogenesis

Mingxue Li 1, Yueying Yang 1,Yang Liu 1, Mengzhu Zheng 2, Dejuan Sun 1*, Hua Li 1,2*, Lixia Chen 1*   

  1. 1. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2020-08-09 Accepted:2020-12-21 Online:2021-02-20 Published:2021-03-02
  • Contact: Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986463; E-mail: i_hua@hust.edu.cn (Hua Li), syzyclx@163.com (LiXia Chen), 760633805@qq.com (DeJuan Sun). E-mail:i_hua@hust.edu.cn;syzyclx@163.com;760633805@qq.com

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摘要： Cancer is a serious threat to human life and a big problem in clinical treatment. Some natural active substances extracted from Traditional Chinese Medicine can effectively inhibit the growth of cancer cells, which is a new direction for finding more effective anticancer drugs. Osthole is a natural coumarin compound extracted from Traditional Chinese Medicines such as Cnidium monnieri, Angelica pubescens and Peucedanum praeruptorum Dunn. It has significant inhibitory activity against a variety of cancers. This paper summarizes the anticancer effects and molecular mechanisms of osthole in the treatment of cancers in recent years in order to provide references for further research.

关键词: osthole, anticancer effects, molecular mechanisms

Abstract: Cancer is a serious threat to human life and a big problem in clinical treatment. Some natural active substances extracted from Traditional Chinese Medicine can effectively inhibit the growth of cancer cells, which is a new direction for finding more effective anticancer drugs. Osthole is a natural coumarin compound extracted from Traditional Chinese Medicines such as Cnidium monnieri, Angelica pubescens and Peucedanum praeruptorum Dunn. It has significant inhibitory activity against a variety of cancers. This paper summarizes the anticancer effects and molecular mechanisms of osthole in the treatment of cancers in recent years in order to provide references for further research.

Key words: osthole, anticancer effects, molecular mechanisms

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