Exploring the anti-hepatoma effect and potential targets of the active components from Gentiana rhodantha Franch ex Hemsl

摘要/Abstract

摘要： The screening of lead compounds in plants is an important way to develop new drugs. Gentiana rhodantha Franch ex Hemsl, belonging to genus Gentiana of Gentianaceae family, has the functions of clearing heat and drying dampness, detoxifying and purging fire, relieving cough and so on. Previous studies have shown that many compounds in G. rhodantha have antitumor activities, but the mechanism is still unclear. The purpose of this study was to investigate the anti-hepatoma activity of the compounds in G. rhodantha by using the knowledge of network pharmacology. A compound-cancer target network with 57 candidate molecules and 38 potential targets was constructed. Analysis of the models showed that the most effective compound in this plant might be compound 47 (rhyncoside D) ether, and the most potential target might be GMP synthase (2vxo). We believe that the present study can provide important clues for the study of anti-hepatoma activity.

关键词: Gentiana rhodantha Franch ex Hemsl, hepatocellular carcinoma, network pharmacology

Abstract: The screening of lead compounds in plants is an important way to develop new drugs. Gentiana rhodantha Franch ex Hemsl, belonging to genus Gentiana of Gentianaceae family, has the functions of clearing heat and drying dampness, detoxifying and purging fire, relieving cough and so on. Previous studies have shown that many compounds in G. rhodantha have antitumor activities, but the mechanism is still unclear. The purpose of this study was to investigate the anti-hepatoma activity of the compounds in G. rhodantha by using the knowledge of network pharmacology. A compound-cancer target network with 57 candidate molecules and 38 potential targets was constructed. Analysis of the models showed that the most effective compound in this plant might be compound 47 (rhyncoside D) ether, and the most potential target might be GMP synthase (2vxo). We believe that the present study can provide important clues for the study of anti-hepatoma activity.

Key words: Gentiana rhodantha Franch ex Hemsl, hepatocellular carcinoma, network pharmacology

Dingding Zhang, Zhuoyang Cheng, Xiaoxiao Huang. Exploring the anti-hepatoma effect and potential targets of the active components from Gentiana rhodantha Franch ex Hemsl[J]. 亚洲传统医药, 2021, 16(6): 367-373.

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