亚洲传统医药

本期目录

2021年, 第16卷, 第6期　刊出日期：2021-12-30 上一期   

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A network pharmacological study on the mechanism of Commiphora myrrha in the treatment of prostate cancer Jiaoyang Hou, Guodong Yao 2021 (6):  329-350.  摘要 ( 338 )   PDF(8526KB) ( 411 )   Background: Prostate cancer (PCa) is one of the most common malignancies of the male genitourinary system. Commiphora myrrha (CM) has the potential to treat PCa, but the underlying mechanism is still unclear. Therefore, this study uses the network pharmacology method to investigate the target of CM in the treatment of PCa and related signal pathways, and further analyze the theoretical basis and potential mechanism of its treatment with PCa. Methods: All the components and targets of CM were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). GeneCards andDisGeNET databases were used to collect PCa-related targets. String was used to build a target protein interaction network. The network of “active component-interaction target-related pathways” and protein-protein interaction network were constructed using Cytoscape, the functional enrichment analysis of GO and the enrichment analysis of KEGG pathway of CM in the treatment of PCa were performed using Metascape. Results: A total of 33 active ingredients including quercetin, β-sitosterol and ellagic acid were obtained, and 61 common targets of CM for PCa were obtained by screening intersection. The most frequent occurrences were AKT1, TP53, JUN, VEGFA, etc. These targets were mainly involved in biological processes, such as apoptotic signaling pathway, response to growth factor, and reactive oxygen species metabolic process, and were mainly concentrated in PI3K-Akt, MAPK and other signaling pathways. Conclusion: This study revealed the effective ingredients, potential targets and mechanism of action of CM in the treatment of PCa, aiming to provide a theoretical basis and reference for subsequent experimental studies. 相关文章 | 计量指标

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Identification and quantitative estimation of Emodin in Rhei Emodi Wall. Rhizome and the relevant polyherbal ayurvedic formulation Ajay Kumar Meena, R. Ilavarasan, Arjun Singh, Lavkush Sharma, Amit Dixit, N. Srikanth 2021 (6):  351-366.  摘要 ( 293 )   PDF(3441KB) ( 298 )   The present study explored quality control of plant drug and polyherbal formulation using HPTLC and HPLC fingerprinting. The study combined qualitative analysis of Emodin and Rhein biomarker compound in Rhei Emodi Wall. rhizome extract and polyherbal formulation extract by HPTLC method with quantitative estimation of Emodin by HPLC method, aiming to help in accurate identification of Emodin and Rhein in plant materials, polyherbal formulations. This study also checked adulteration, with the purpose of improving bio-efficacy of ayurvedic formulation. All the samples showed characteristic peaks of Emodin at same retention time as that of standard Emodin. According to the HPTLC fingerprinting results, the Rf values of Rhein reference standard at 0.42 and Emodin at 0.62 were observed in test solution of Rhei emodi Wall. rhizome extract and polyherbal formulation extract and both were found comparable. The quantitative evaluation of Emodin present in the polyherbal formulation and Rhei emodi Wall. rhizome extracts were 0.0177% and 0.3106% respectively. 相关文章 | 计量指标

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Exploring the anti-hepatoma effect and potential targets of the active components from Gentiana rhodantha Franch ex Hemsl Dingding Zhang, Zhuoyang Cheng, Xiaoxiao Huang 2021 (6):  367-373.  摘要 ( 314 )   PDF(2057KB) ( 269 )   The screening of lead compounds in plants is an important way to develop new drugs. Gentiana rhodantha Franch ex Hemsl, belonging to genus Gentiana of Gentianaceae family, has the functions of clearing heat and drying dampness, detoxifying and purging fire, relieving cough and so on. Previous studies have shown that many compounds in G. rhodantha have antitumor activities, but the mechanism is still unclear. The purpose of this study was to investigate the anti-hepatoma activity of the compounds in G. rhodantha by using the knowledge of network pharmacology. A compound-cancer target network with 57 candidate molecules and 38 potential targets was constructed. Analysis of the models showed that the most effective compound in this plant might be compound 47 (rhyncoside D) ether, and the most potential target might be GMP synthase (2vxo). We believe that the present study can provide important clues for the study of anti-hepatoma activity. 相关文章 | 计量指标

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A review: The chemical components and pharmacological activities of Piper auritum Kunth Jiayi Wang, Weiyu Zhou, Xiaoxiao Huang, Shaojiang Song 2021 (6):  374-384.  摘要 ( 460 )   PDF(1020KB) ( 463 )   Piper auritum Kunth, a member of the Piperacea family, is a small shrub native to the Central American tropics. This plant was traditionally used in Latin American countries for the treatment of various medical conditions. Increase in the recent studies of P. auritum’s chemical components leads to the isolation of monoterpenoids, sesquiterpenoids, phenylpropanoids and several other compounds. Previous research has revealed that these secondary metabolites have diverse pharmacological activities including antidiabetic, antioxidant, anti-inflammatory, anti-pathogeny microorganism and repellent activity. This review summarizes relevant findings on P. auritum, and hopes to contribute to the exploration of its potentials for further development as an alternative medicine. 相关文章 | 计量指标

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Research progress on flavonoids from the roots of Sophora flavescens Alt. and their biological activities Guoqing Long†, Jue Wang†, Dongyu Min, Yang Xu, Jingming Jia, Anhua Wang 2021 (6):  385-397.  摘要 ( 327 )   PDF(1825KB) ( 716 )    Sophora flavescens Alt., a perennial herb of Sophora in Leguminosae family, was widely distributed in the north and south of China. Its root is utilized as a traditional Chinese medicine to clear heat, drain dampness, kill insect and promote urination by virtue of bitter and cold. Its chemical components are complex and diverse, mainly including alkaloids and flavonoids. Modern pharmacological studies have found that prenylflavonoids and quinolicidine alkaloids are the characteristic chemical constituents and the main active ingredients, with anti-inflammatory, anti-tumor, anti-oxidation, and other various biological activities. This study reviewed the chemical constituents of S. flavescens and the pharmacological effects of flavonoids in it in order to provide reference for further development. 相关文章 | 计量指标