亚洲传统医药

本期目录

2023年, 第18卷, 第2期　刊出日期：2023-04-27 上一期   

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Predicting ADME/Tox properties of hydroxytyrosol in the leaves of Olea europaea L. Suzhen Jiang, Xinghua Liu, Hongjian Yu, Shihong Li, Jingming Jia, Anhua Wang 2023 (2):  45-53.  摘要 ( 151 )   PDF(1823KB) ( 159 )   In order to study the possibility of hydroxytyrosol (HT) as a drug, we used SwissADME system to predict ADME of HT and pkCSM system to predict Tox of HT. The results show that hydroxytyrosol meets the Lipinski’s five principles of drug-like properties. With strong efficacy and pharmacological activity, HT has high drug-likeness degree. With good bioavailability, it can be easily absorbed by the gastrointestinal tract, though not absorbed by skin. Hydroxytyrosol has not only a strong potency and pharmacological activity, but also no liver toxicity and skin allergy. Tox data predicts that it has mutagenic potential, which may be the result of overreduction. 相关文章 | 计量指标

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Study on the pharmacological activities and chemical structures of Viburnum dilatatum Zhiheng Gao, Yufei Xi, Man Wang, Xiaoxiao Huang, Shaojiang Song 2023 (2):  54-59.  摘要 ( 120 )   PDF(3063KB) ( 61 )   Viburnum dilatatum (jiami in Chinese), belonging to the Caprifollaceae family, is widely distributed in Japan and China. Phytochemical investigations of Viburnum dilatatum (V. dilatatum) have resulted in the isolation of triterpenoids, phenolic glycosides essential oil, norisoprenoids, etc. Research results have shown that the chemical constituents of V. dilatatum possess various pharmacological activities, including antihyperglycemic, antioxidant activity and antiulcer effects. This study reviewed the chemical constituents and pharmacological activities of V. dilatatum to provide practical and useful information for further research and development of this plant. 相关文章 | 计量指标

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Chemical compositions and biological activities of Flos lonicerae Yi’an Shi, Luming Pan, Luyan Yang, Jing Sun, Meng Zhang, Yu Chen 2023 (2):  60-68.  摘要 ( 126 )   PDF(906KB) ( 67 )   Flos lonicerae is the dry flower bud of Lonicera japonica Thunb, and it is a very important Chinese herbal medicine in China. In ancient times, it was widely used to treat the exopathogenic wind-heat, epidemic febrile diseases, sores, carbuncles and some infectious diseases. Modern pharmacological research has indicated that it has anti-inflammatory, anti-bacterial, anti-viral and anti-oxidation activities. This paper reviews the chemical compositions and biological activities of Flos lonicerae in order to provide reference for its application in clinical practice in the future. 相关文章 | 计量指标

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Chemical constituents and pharmacological activities of Salvia miltiorrhiza Man Wang, Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang 2023 (2):  69-80.  摘要 ( 135 )   PDF(1305KB) ( 90 )   Salvia miltiorrhiza Bunge (S. miltiorrhiza), a perennial plant of the genus Salvia, is widely used in traditional folklore medicine. Previous chemical research on this plant contains diterpenoid quinones, phenolic acids, polysaccharides and other compounds. The pharmacological investigation of S. miltiorrhiza has shown that it has various pharmacological activities, such as cardiovascular system protection, anti-inflammatory, anti-oxidant, anti-tumor, liver protection, and neuroprotection activities. This research tends to give an overview of the main chemical constituents and pharmacological effects of S. miltiorrhiza, aiming to reveal its potential value and provide reference for its further development. 相关文章 | 计量指标