亚洲传统医药

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2013年, 第8卷, 第3期　刊出日期：2013-06-20 上一期    下一期

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A novel method for quality control of herbal medicine using normal and reversed fingerprints with Linear System Quantified Fingerprints Method Guoxiang Sun*;Junmei Xia;Yanfei Li 2013 (3):  57-68.  摘要 ( 496 )   Chromatographic normal and reversed fingerprints coupled with Linear System Quantified Fingerprints Method (LSQFM) were proposed for quality control of traditional Chinese medicine (TCM) by high performance liquid chromatography (HPLC)- photodiode array detection. The method was performed to evaluate the quality of Yinhuang Tablet (YHT). Statistical analysis of the obtained data demonstrated that our method has achieved ideal precision and accuracy. Normal and reversed fingerprints analysis can monitor both the contribution of high content compositions and low or trace constituents, which are rarely investigated because their contents are low, their preparation and characterization are difficult. Due to the different contribution of the eight biggest and smallest peaks in the normal and reversed fingerprints, a few batches of samples had the intuitive contrast of SL, ML, α and quality grade in fingerprint analysis. These results demonstrated that normal and reversed fingerprints by LSQFM can offer an efficient and reliable approach for quality consistency evaluation of TCM. 相关文章 | 计量指标

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Synthesis, characterization study of a lead-based indian traditional drug: Naga bhasma Chandrashekhar Bhingare *;Smita Deshmukh;Sanjay Kshirsagar 2013 (3):  69-78.  摘要 ( 520 )   Naga bhasma is a organo-metallic preparation. It is prepared using lead and different herbs and found effective in the treatment of diseases such as diarrhea, spleen enlargement and diabetes. Lead is considered as poisonous heavy metal but products containing Naga bhasma are non-toxic it is used by medical professionals practicing Ayurveda. Naga bhasma is manufactured by the procedures described in Ayurvedic literature. Different methods of preparation are available in Ayurveda but the standard monograph is unavailable. The present work is an attempt to establish parameters for standardization of Naga bhasma. According to one of the references following method for preparation of Naga bhasma involves quenching of molten lead into different herbal juices. Grinding and heating of this material several times generates specific organo-metallic complex. Quenching with Til Oil (sesame oil), Buttermilk, Gomutra (Cow’s Urine), Kanji (Starch Paste), (Kulittha Kwatha) purifies Lead and mixing and stirring to get powder blend with bark Ashwattha (Ficus religiosa) and Amlika (Tamrindus indica) followed by heating and grinding with Turmeric powder and Aloe vera juice removes toxicity to generate specific organo-metallic complex. The parameters (form, nature and particle size) of Naga bhasma were characterized based on structural and elemental basis, using XRD, IR, AAS, SEM with EDAX and DSC. Acceptance criteria at various stages of preparation of the Naga bhasma were established based on the above method results. The work will help to changes occurring different stages of bhasma, standardize the raw material specifications, process parameters, in- process specifications and finished product (Naga bhasma) specifications. 相关文章 | 计量指标

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Amorphophallus campanulatus Roxb. : A herbal remedy for the treatment of hyperandrogenism associated with polycystic ovary evaluated using a rat model Mamata Jadhav *;Sasikumar Menon;Sunita Shailajan 2013 (3):  79-87.  摘要 ( 456 )   New options are needed to treat the hormonal disorders associated with polycystic ovary syndrome (PCOS). The objective of the study was to investigate the effect of Amorphophallus campanulatus Roxb. (AC), a herbal remedy, for the treatment of polycystic ovary syndrome (PCOS) in a Letrozole-induced PCOS rat model and to compare the protective effect of Clomiphene citrate with AC. PCOS was induced in albino Wistar female rats by daily oral administration of Letrozole for 21 days. A low (250 mg/kg), mid (500 mg/kg) and high dose (1000 mg/kg) of AC was given orally to the PCOS induced rats for 15 days post Letrozole induction to determine the effective dose of AC for the treatment of PCOS. The biomarkers of ovarian function, plasma testosterone, estrogen and progesterone, were analyzed to determine the fluctuations in sex steroid levels in rats with PCOS induced by Letrozole. The plasma testosterone levels were found to be significantly increased in rats with PCOS whereas plasma estrogen and progesterone levels were found to be decreased. When compared with controls, the PCOS rats were characterized by the high incidence of ovarian cysts with a diminished granulosa layer, significantly atretic follicles and absence of corpora lutea. All the end points assessed were significantly improved by a high dose of AC and reached almost normal levels. The high dose (1000 mg/kg) of AC was found to be effective for the treatment of PCOS induced by Letrozole in rats. This effect of AC prevented ovarian histopathologic, endocrine and biochemical alterations induced by hyperandrogenism. Thus, AC was found to have the potential to be a very good alternative therapy for the treatment of PCOS. 相关文章 | 计量指标