亚洲传统医药

本期目录

2021年, 第16卷, 第2期　刊出日期：2021-04-25 上一期    下一期

Regular Article

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Isolation and structural elucidation of the compounds from the fruits of Camptotheca acuminate Jingxian Ren, Zhuoyang Cheng, Huan He, Xiaoxiao Huang, Shaojiang Song 2021 (2):  69-75.  摘要 ( 338 )   PDF(866KB) ( 325 )   The fruit of Camptotheca acuminate is used as a traditional Chinese medicine. Eight compounds were isolated from the fruit of Camptotheca acuminate for the first time, including (+)-(S)-abscisic acid (1), blumenol A (2), (E)-3-hydroxymegastigm-7-en-9- one (3), (-)-(3R)-3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin (4), (-)-(3R)-8-methoxy-3-methyl-3,4-dihydro-1H-isochromen- 1-one (5), neocnidilide (6), (3S)-butylphthalide (7) and senkyunolide I (8). Their structures were determined by comprehensive spectroscopic methods, including HRESIMS and 1D NMR. 相关文章 | 计量指标

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Secondary metabolites from an endophytic fungus Aspergillus fumigatus from Solanum insanum L. M. Vindya Kanthi Munasinghe, N. Savitri Kumar, Nimal Adikaram, Lalith Jayasinghe, Hiroshi Araya, Yoshinori Fujimoto 2021 (2):  76-82.  摘要 ( 274 )   PDF(906KB) ( 612 )   An endophytic fungus Aspergillus fumigatus, isolated from the fruits of Solanum insanum L., was cultured in potato dextrose broth medium. Chromatographic separation of the EtOAc extract led to the isolation of six secondary metabolites, identified as pseurotin A (1), fumigaclavine C (2), monomethylsulochrin (3), trypacidin (4), fumiquinazoline C (5) and guignasulfide (6) by spectral means. Compounds 2 and 3 showed brine shrimp toxicity with IC50 values of 147 and 74.2 μM, respectively, while compounds 4 and 5 showed slight inhibition on the growth of fungal pathogen Cladosporium cladosporioides. This is the first report of the isolation of guignasulfide (6) from A. fumigatus, which has been previously isolated only from an endophytic fungus Guignardia sp. 相关文章 | 计量指标

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Determination of seven active components in Salvia miltiorrhiza herb by matrix solid phase dispersion combined with ion liquid#br# extraction followed by high performance liquid chromatography Bo Hong, Yanping Wang, Yinglong Han, Wenjing Li 2021 (2):  83-97.  摘要 ( 212 )   PDF(1143KB) ( 293 )   A low cost, rapid and sensitive preparation method of silica gel supported ionic liquid (SGSIL) combined with matrix solid phase dispersion (MSPD) followed by high performance liquid chromatography (HPLC) with ultraviolet detection (UV) is proposed, and it was applied to determine the seven active compounds in Salvia Miltiorrhiza herb. SGSIL and ionic liquid [BMIM]BF4 were used as the adsorbent and the green elution reagent in the MSPD procedure. Several extraction conditions including type of filler and elution solvent, the volume of elution solvent, material liquid ratio were optimized. Under the optimum conditions, the SGSIL-MSPD-HPLC method showed a low limit of detection (LOD, S/N = 3) of 0.0122-0.8788 μg/mL for standard solution, limit of quantification (LOQ, S/N = 10) of 0.0406-2.9292 μg/mL for standard solution, wide linear range from 1.56 to 2000 μg/mL for all compounds for standard solution, correlation coefficients (r) of more than 0.9990, acceptable reproducibility (relative standard deviations, RSDs < 3.54%), and precision of RSDs < 3.36% for intra-day, RSDs < 3.50% for inter-day. The satisfactory recoveries ranged from 96.4 to 102.5, with RSDs less than 3.45%. The developed SGSIL-MSPD method is easier and more suitable for the determination of the seven active compounds in Salvia Miltiorrhiza herb than the traditional ultrasonic extraction. It was an effective and efficient method for the extraction and quantification of the seven active compounds in traditional Chinese herbal samples. 相关文章 | 计量指标

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Isolation and identification of chemical constituents from Elephantopus scaber Linn. Wei Xu, Ming Bai, Xiaoxiao Huang 2021 (2):  98-104.  摘要 ( 227 )   PDF(1075KB) ( 419 )   Elephantopus scaber L., as a popular Chinese medicinal herb of the Compositae family, is widely distributed in America, Africa and Asia. In the present study, five compounds were isolated from the 70% EtOH extract of the whole herb from Elephantopus scaber L., including two lignans and three flavones. Their chemical structures were identified based on NMR spectroscopic analysis and comparison with the data reported in literature. It is noteworthy that compounds 1-5 were isolated from Elephantopus scaber L. for the first time and their chemotaxonomic significance was discussed. 相关文章 | 计量指标

Review

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Research review on the chemical constituents and pharmacological effects of Piper hancei Yilin Zhao, Peiyuan Yang, Jiaxin Chen, Lili Lou 2021 (2):  105-113.  摘要 ( 278 )   PDF(1061KB) ( 337 )   Traditional Chinese medicine “Shanju”, the dry stem of Piperaceae plant Piper hancei Maxim, is mainly distributed in southern China. Historically, P. hancei has been used as a substitute for the traditional Chinese medicine “Haitengtong” to treat rheumatism, joint pain, and asthma. At present, chemical constituents of it have been reported. In order to review the advances in chemical and pharmacologic studies and discuss the potential prospects for future investigation, the report summarized over 92 compounds isolated from P. hancei, including alkaloids, organic acid, sterol, aglycone, lignans, volatile oil and others. These compounds exhibited a wide range of bioactivities, such as anti-inflammation, inhibition of platelet aggregation, insecticidal effects and bactericidal activity. 相关文章 | 计量指标