亚洲传统医药

本期目录

2021年, 第16卷, 第3期　刊出日期：2021-06-25 上一期    下一期

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A network pharmacology-based study on the effect of Periploca forrestii Schltr. on hepatocellular carcinoma Shuang Qiu, Peng Zhao, Xiaoxiao Huang, Shaojiang Song 2021 (3):  115-124.  摘要 ( 252 )   PDF(3836KB) ( 326 )   Hepatocellular carcinoma (HCC) remains the sixth most common malignancy and the fourth leading cause of cancer death worldwide. Numerous Chinese herbs have been used to prevent and treat HCC. Periploca forrestii Schltr., belonging to the family of Asclepiadaceae, has been reported to have strong inhibitory efficacy against various types of cancer cells, but the mechanism is unclear. Hence, we utilized the compound-disease target network based on the network pharmacology analysis to find out the active ingredients from P. forrestii and the potential target proteins involved in hepatocellular carcinoma. The results showed that the most effective compounds in this plant might be caffeoylquinic acids and the most potential target might be GMP synthase [glutamine-hydrolyzing] (PDB: 2vxo). This study is of great significance to the further research of P. forrestii and provides a novel treatment strategy for HCC. 相关文章 | 计量指标

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Network pharmacology analysis of the mechanisms of Banxia Xiexin Decoction against Ulcerative Colitis Shuang Xu, Tonghui Yu, Dan Yuan 2021 (3):  125-138.  摘要 ( 273 )   PDF(4519KB) ( 296 )   Banxia Xiexin Decoction (BXXXD), a traditional herbal formula, has been used to treat ulcerative colitis (UC) clinically. In this study, chemical compounds and putative targets of BXXXD and UC related therapeutic targets were screened from multiple databases. The protein-protein interaction (PPI) was conducted using String database, and 31 candidate targets were screened from CytoNCA database. The Database for Annotation, Visualization and Integrated Discovery (DAVID) and Metascape database were used for Kyoto Encyclopedia of Genes and Genomes (KEGG) channel and Gene Ontology (GO) enrichment analysis respectively, and the enrichment analysis results were visualized by OmicShare platform. Meanwhile, the interaction network among Chinese herbs, active compounds, candidate targets and pathways was built by Cytoscape 3.7.2 software, and the potential compounds of BXXXD in the treatment of UC were screened. Finally, molecular docking technology was used to verify the putative key compounds. Combined with literature research, 5 key compounds for the treatment of UC were identified, which are mainly involved in TNF signaling pathway, cancer signaling pathway, inflammatory bowel disease (IBD), Toll-like receptor signaling pathway, and NF-κB signaling pathway. This study provides a scientific basis for BXXXD as an effective alternative therapeutic agent for UC from a new perspective, and also provides a feasible method for basic chemical research and pharmacological research of BXXXD. 相关文章 | 计量指标

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Protective effect of 4-methyl-2-{[4-(toluene-4-sulfonyl)-thiomorpholine-3-carbonyl]-amino}-pentanoic acid isopropyl ester against cerebral ischemia Tinghui Zhang, Yihan Wang, Xin Li, Jinwei Dai, Quankun Zhuang, Xirui Song, Junhai Xiao, Lili Wang, Yuyang Zhang 2021 (3):  139-152.  摘要 ( 343 )   PDF(2487KB) ( 274 )   To investigate the effects of 4-methyl-2-{[4-(toluene-4-sulfonyl)-thiomorpholine-3-carbonyl]-amino}-pentanoic acid isopropyl ester (HD5-6) against cerebral ischemia in rodents, the models with global and focal ischemia were induced by bilateral common carotid artery occlusion plus hypotension (BCAOH) and permanent cerebral artery occlusion (p-MCAO) in mice (n = 10 – 12 per group in BCAOH; n = 8 per group in p-MCAO) and rats (n = 10 - 11 in each group). HD5-6 prolonged lifetime and improved neurological function. Neurological deficits score in HD5-6 (30 mg/kg) decreased significantly. Malonaldehyde (MDA) in HD5-6-treated mice with ischemia considerably dropped. The infarction volume of the HD5-6-treated rats with MCAO-induced ischemia decreased significantly in the high dose group (P < 0.05, i.g. and P < 0.01, i.v.). Immunohistochemistry showed that Brain derived neurotrophic factor (BDNF) in the ipsilateral hemisphere increased and Vascular endothelial growth factor (VEGF) decreased with HD5-6 treatment. HD5-6 has protective effects against experimental cerebral ischemia in rodents and the action mechanism may involve anti-oxidation and neurogenesis. 相关文章 | 计量指标

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A review of phytochemistry and pharmacology perspectives of Clitoria ternatea L. Dingding Zhang, Zhuoyang Cheng, Xiaoxiao Huang 2021 (3):  153-160.  摘要 ( 543 )   PDF(1019KB) ( 641 )   Clitoria ternatea L., belonging to the family Fabaceae and subfamily Papilonaceae, is an herbaceous perennial legume valued for its medicinal importance. Pharmacological investigations on this plant have shown it has a variety of medicinal properties, including antibacterial activities, antitumor activities, antioxidant activities, memory enhancing activities, wound healing activities, antipyretic activities and antiasthmatic activities. However, there are few studies on the chemical constituents of C. ternatea. The present research reviewed the chemical constituents and biological activities of C. ternatea to provide references for further research on this plant. 相关文章 | 计量指标

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Research progress on chemical constituents in Sigesbeckiae Herba and their pharmacological activities Meiya Lian, Xiaoxu Gao, Jingming Jia, Anhua Wang 2021 (3):  161-184.  摘要 ( 289 )   PDF(1493KB) ( 396 )   Sigesbeckiae Herba, a dry whole plant of Sigesbeckia glabrescens Makino, Sigesbeckia pubescens Makino and Sigesbeckia orientalis L., is a traditional Chinese medicine used to dispel dampness, dredge meridians and collaterals, clear heat and detoxicate. Its chemical components are complex and abundant, including mainly diterpenoids, sesquiterpenoids and flavonoids. Among them, diterpenoids are the main active components. Modern pharmacological studies have found that the compounds isolated from Sigesbeckiae Herba have anti-inflammatory, anti-tumor, antithrombus and other pharmacological activities. This review systematically summarized the chemical components identified from Sigesbeckiae Herba and their pharmacological activities by searching Chinese and English databases, in order to provide references for the further development of Sigesbeckiae Herba and the improvement of its quality standards. 相关文章 | 计量指标