亚洲传统医药

本期目录

2022年, 第17卷, 第1期　刊出日期：2022-02-25 上一期    下一期

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Chemical components from Crotalaria pallida Ait. and their antioxidant activities Shuai Shen, Ming Bai, Shaojiang Song 2022 (1):  1-8.  摘要 ( 179 )   PDF(860KB) ( 347 )   Nine compounds were isolated from the 95% ethanol extract of the dried seeds of Crotalaria pallida. The structures of all compounds were identified through the analysis of spectral data. All compounds were isolated for the first time from Crotalaria genus. Compounds 1-5 were evaluated for their antioxidant abilities by ABTS, DPPH and FRAP assays. Results showed that compounds 1-5 had moderate antioxidant activities. 相关文章 | 计量指标

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Network pharmacology-based analysis on the anti-hepatocellular carcinoma effect of Curcumae Radix Shuyan Qin, Guodong Yao 2022 (1):  9-24.  摘要 ( 174 )   PDF(4670KB) ( 268 )   As a traditional Chinese medicine, Curcumae Radix (CR) has exhibited anti-hepatocellular carcinoma (HCC) activity. However, the underlying molecular mechanism is still unclear. In the present study, network pharmacology was utilized to reveal the mechanism of the effects of CR in HCC. The analysis of the network results showed that the active components of CR, including curcumin, naringenin, sitosterol, demethoxycurcumin, and β-elemene, were closely related to the screened hub-targets, such as AKT1, TP53, MAPK8, MAPK1, JUN, STAT3, VEGFA, MAPK3, IL6, TNF, CCND1, EP300, EGFR, and ESR1. GO and KEGG analyses revealed that these targets were associated with pathways in cancer, proteoglycans in cancer, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, MAPK signaling pathway, hepatitis B, hepatitis C, and other biological processes. The candidate active components of CR (curcumin and naringenin) prominently exhibited their antitumor effects by regulating PI3K-Akt signaling pathway, MAPK signaling pathway, hepatitis B and hepatitis C. This study successfully predicted, explained, and confirmed the multi-component, multi-target, and multi-channel characteristics of CR, which not only gave novel insights into the pharmacological and biological molecular mechanism of CR applying to HCC disease, but also provided a feasible method for discovering potential activated compounds from Chinese herbs. 相关文章 | 计量指标

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A review of research on the main chemical constituents and pharmacological effects of Daphne odora Thunb. Ruoyu Jiang, Peng Zhao, Lili Lou 2022 (1):  25-31.  摘要 ( 218 )   PDF(1154KB) ( 308 )   Plant of Daphne odora Thunb. has been used as medicinal plant since ancient times. In recent years, phytochemical studies have found that D. odora contains flavonoids, diflavonoids, coumarins, lignans, monoterpenes and other compounds, and shows extensive biological activities such as anti-inflammatory, immunomodulatory, neuroinhibition effects and so on. This article briefly reviews the recent research progress on the chemical constituents and pharmacological effects of D. odora at home and abroad. 相关文章 | 计量指标

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Phytochemical and Pharmacological Properties of Viburnum lantana L. Zhiyuan Li, Peng Zhao, Xiaoxiao Huang 2022 (1):  32-40.  摘要 ( 162 )   PDF(1442KB) ( 316 )   Viburnum lantana L. (Caprifoliaceae) is a shrub up to 3-5 m tall, with red or black drupes. Researchers have studied the chemical composition of different parts of the plant and found many compounds with novel structures, including chalcone glycosides, iridoid glycosides, and some terpenoids. At the same time, it has been reported that the extracts from different parts of V. lantana have a variety of biological activities, including antioxidant, antimicrobial, and AChE Inhibitory activities. This study reviewed the chemical components and bioactivities of the V. lantana reported in recent years. 相关文章 | 计量指标