亚洲传统医药

本期目录

2022年, 第17卷, 第4期　刊出日期：2022-08-25 上一期   

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Uncovering the mechanism of Scutellariae Radix in the treatment of breast cancer based on network pharmacology Qian Li, Shaojiang Song 2022 (4):  143-160.  摘要 ( 263 )   PDF(3036KB) ( 198 )   Breast cancer (BCa) is one of the most common malignant tumors that seriously affect women’s physical and mental health and even endanger their lives. Establishing a primary prevention program for BCa remains a challenge. Traditional Chinese medicine, Scutellariae Radix (SR), has been used to treat BCa while its pharmacological mechanism is still unclear. This study aims to reveal the pharmacological mechanism of SR in the treatment of BCa. Chemical constituents of SR were obtained and the targets of the compound were identified via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). GeneCards and DrugBank databases were used to collect BCa’s related target genes. Disease-compound common target protein interaction network was established by using the STRING database. The network diagrams of the active component action target and protein-protein interaction (PPI) networks were constructed by Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out to further explore the BCa mechanism and therapeutic effect of SR. As a result, 121 active compounds were obtained. The Venn diagram results showed that SR and BCa had 57 intersection targets, the more frequently targeted ones are TP53, JUN, CCND1, AKT1, which could affect biological processes such as response to steroid hormone and positive regulation of cell death. KEGG analysis revealed that these targets were related to IL-17 signaling pathway, p53 signaling pathway and PI3K-Akt signaling pathway. In conclusion, this study preliminarily verified the target and mode of action of SR in the treatment of BCa, laying a foundation for further research on its mechanism. 相关文章 | 计量指标

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Research progress on the lignans from the genus Schisandra and their biological activities Luqi Liu, Xueqing Zhang, Yongcheng Yang, Sanpeng Fan, Jingming Jia, Anhua Wang 2022 (4):  161-180.  摘要 ( 158 )   PDF(2695KB) ( 214 )   The plants of the genus Schisandra belong to the Schisandraceae family. As one of the main active components of genus Schisandra, lignans have rich biological activities, including anti-inflammatory, anti-tumor, anti-HIV and PAF antagonism. This article summarizes and classifies the types and activities of lignans isolated from the genus Schisandra in the past ten years. 相关文章 | 计量指标

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Volatile oil from Litsea lancilimba Merr.: a review of its chemical structure and biological activity Yijie Zhang, Ming Bai, Weiyu Zhou, Xiaoxiao Huang, Shaojiang Song 2022 (4):  181-185.  摘要 ( 114 )   PDF(900KB) ( 109 )   Litsea lancilimba Merr. is a Cinnamomum plant of Lauraceae. Phytochemical investigations of the Litsea lancilimba Merr. have resulted in the isolation of Volatile oil, flavonoid glycosides, tannins, alkaloids, lignans, organic acids and so on. Studies have showed that volatile oil is the main chemical component. Recent trials have demonstrated the efficacy of Litsea lancilimba Merr. in strengthening the function of stomach. The fruits have also been demonstrated to possess anti-inflammatory and bacteriostatic activities. This review deals mainly with the chemical structure and biological activities of Litsea lancilimba Merr. oil. 相关文章 | 计量指标

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A review: Panax ginseng diseases and the control techniques Mo Yao, Liwen Chen, Luming Pan, Haonan Yu, Yuhang Liu, Miao Wang, Yu Chen 2022 (4):  186-191.  摘要 ( 207 )   PDF(789KB) ( 191 )   Panax ginseng (P. ginseng) is a famous traditional medical plant, with both the medical and economic value. In China, the cultivation of P. ginseng is a major agricultural activity. However, the yield and quality have declined in recent years due to various diseases. This review summarized the common diseases of P. ginseng and the controlling techniques, aiming to enhance the cultivation of P. ginseng and ensure the sustainable development of P. ginseng industry. 相关文章 | 计量指标