Asian Journal
Of Traditional Medicines

Abstract: Differentiation therapy has been successfully carried out in acute promyelocytic leukemia patients with
treatments involving all-trans retinoic acid, a natural metabolite of vitamin A, and arsenic trioxide, a
traditional medicine. Using human myeloid leukemia cell lines, many natural products isolated from
traditional herb medicines have been found to have differentiation-induction ability. Compounds from
traditional medicine with cell differentiation effects in leukemia cells are described in this communication.

Key words: traditional herb medicines, differentiation, myeloid leukemia.