Asian Journal
Of Traditional Medicines

Abstract: The purpose of these experiments is to investigate the anti-tumor effect of the compound recipe Radix Sophorae Flavescentis for injection (CRS) in vitro and in vivo. The S180 , H22 , Lewis lung tumor models were established in mice and the inhibition rate of tumor growth was calculated by weighing the tumor after CRS treatment. MTT assay was used to examine its effect on HeLa and HepG-2 cells. CRS (dose: 1.6, 3.2, 6.4 g·mL-1) produced a clear inhibitory effect on the growth of S180, H22, Lewis in tumor-bearing mice, and the inhibition rate was more than 35 % (P < 0.01 vs. control group). The CRS, at a dose of 1-0.25 g·mL-1, significantly inhibited the growth of HeLa and HepG-2 cells in a dose-dependent manner. Following these results, it appears that CRS has marked inhibitory effects on tumor growth in vitro and in vivo.

Key words: CRS, anti-tumor effect, S180, HeLa cell, MTT assay