Asian Journal
Of Traditional Medicines

Abstract: γ-Schisandrin, as one of main active components in Wurenchun, has a very low solubility in water and requires large doses to be effective. The aim of this study was to evaluate the pharmacokinetics and bioavailability of γ-schisandrin from a Wurenchun-PVP k30 solid dispersion (WSD) and conventional self-prepared capsules (CSP). A selective, accurate and simple high performance liquid chromatography (HPLC) method was established and the plasma concentration profiles and pharmacokinetic parameters of γ-schisandrin in rats were investigated after oral administration of WSD and CSP. The results revealed that the bioavailability of γ-schisandrin in rats administrated WSD increased significantly compared with the CSP. The pharmacokinetic results of γ-schisandrin in rats after i.g. WSD or CSP demonstrated the existence of marked gender-dependent differences. The C_max and AUC values of γ-schisandrin in female rats after i.g. WSD and CSP were found to be about 3-fold and 6-fold higher, respectively, than those in male rats. This gender difference could be helpful in determining the appropriate dosage of WSD and its preparations.

Key words: pharmacokinetics, bioavailability, γ-schisandrin, solid dispersion, gender difference.