Asian Journal
Of Traditional Medicines

Abstract:

The work sought to establish the neuropharmacological effect of the crude extract of the leaves of Struchium sparganophora in mice. The neuropharmacological activity was investigated using novelty-induced rearing and grooming behaviors, locomotor activity, hypothermic effect and ketamine-induced sleeping time. The results shows that the crude extract produced a reduction in novelty-induced rearing and grooming behaviors, decreased locomotor activities and reduced rectal body temperature. The extract decreases the onset and potentiates ketamine-induced sleeping time. It was concluded that the crude extract possessed central nervous system depressant properties in mice.

Key words: Struchium sparganophora, rearing, grooming, locomotion, hypothermia