Asian Journal
Of Traditional Medicines

Abstract: The present study was designed to carry out comparative and combined studies to screen anti-diabetic, anti-oxidant and hypolipidemic studies of Ficus racemosa Linn. (Gular) fruit extract (FRE) and Aegle marmelos (Bael) root extract (AME) in various experimental models of ulcer. Diabetes was induced by Streptozotocin (STZ) 50 mg/kg intraperitoneally. Serum glucose levels were estimated using GOD-POD method. Total lipids, total cholesterol were estimated using kits. Other biochemical parameters like thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were estimated in liver and kidney homogenates spectrophotmetrically. FRE fruit extract has shown more degree of anti-hyperglycemic activity and anti-oxidant activity than AME root extract does. But, both have produced similar degree of hypolipidemic activity. Moreover, among the combinations A1, A2 & A3, combination A3 has shown more degree of efficacy at lower dose combinations than the individual biological effects of these two plant extracts. FRE fruit extract and AME root extract exhibits potent anti-hyperglycemic, anti-oxidative and anti-hyperlipidemic activity in STZ diabetic rats. There appears to be more beneficial outcome when these plant extracts are combined. These results support herbal combinations in the treatment of diabetes and cardiovascular disease.

Key words: Aegle marmelos, Ficus racemosa, herbal combination, hyperglycemia, oxidative stress, hyperlipidemia