In vitro screening of the cytotoxic, antibacterial and antioxidant activities of some Uzbek plants used in folk medicine

›› 2012, Vol. 7 ›› Issue (2): 73-80.

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In vitro screening of the cytotoxic, antibacterial and antioxidant activities of some Uzbek plants used in folk medicine

Sobirdjan A. Sasmakov 1*, Zhanna M. Putieva 1, Shakhnoz S. Azimova 1, Ulrike Lindequist 2

1. Uzbek Academy of Sciences, S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Tashkent 100170, Uzbekistan; 2. Institute of Pharmacy, Department of Pharmaceutical Biology, University of Greifswald, D-17487, Germany

Received:2011-06-07 Revised:2012-04-15 Online:2012-04-20 Published:2012-04-20
Contact: Sobirdjan A. Sasmakov

Abstract

Abstract: The present work evaluated the antitumor, antibacterial and antioxidant activity of extracts from 24 plants used in Uzbek traditional medicine. The chloroformic extracts of Ecballium elaterium, Conium maculatum, Dodartia orientalis, Peganum harmala, Salvia sclarea, Tragopogon malicus and Vaccaria segetalis exhibited strong cytotoxicity with IC50 values ranging between 3.94 and 19.5 µg/ml. The methanolic extracts of Coronaria coriacea, Ligularia macrophylla, Otostegia bucharica, Phlomis bucharica, Salvia aethiopis, S. sclarea, Vaccaria segetalis and Zygophyllum gontscharovii showed remarkable antibacterial activity against both Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, and only the extract from Acanthophyllum albidum showed potent antifungal activity against Candida maltosa. The methanolic extracts of 7 plant species showed effective free radical scavenging in the DPPH assay.

Key words: cytotoxic, antibacterial, antioxidant activity, Uzbek plant

Sobirdjan A. Sasmakov *;Zhanna M. Putieva;Shakhnoz S. Azimova;Ulrike Lindequist . In vitro screening of the cytotoxic, antibacterial and antioxidant activities of some Uzbek plants used in folk medicine[J]. , 2012, 7(2): 73-80.

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In vitro screening of the cytotoxic, antibacterial and antioxidant activities of some Uzbek plants used in folk medicine

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Of Traditional Medicines