Asian Journal
Of Traditional Medicines

Abstract: The root of Capparis zeylanica Linn. in particular is recommended for CNS problem and traditionally it used as analgesic by
some tribe in accidental pain. The purpose of the present study is to evaluate the analgesic, anti-inflammatory and antipyretic
effect of the methanolic and water extracts using different acute and chronic models of rat and mice. Fresh root of the plant was
collected at the flowering stage in December from university campus. Air-dried and powdered roots were Soxhlet extracted in
water and alcohol. Extracts were phytochemicaly screened by standard methods showing the presence of alkaloids, flavonoids,
saponins, phenols and tannins. Both the extracts were evaluated for analgesic, in-flammatory and anti-pyretic study by pre
reported methods. It was observed that both the extracts contain phenolic compounds, tannins, flavonols, alkaloids, sapoinins and
flavonoids. The extracts (200–400 mg/kg) of Capparis zeylanica root showing dose-dependent and significant (P<0.05) increases
in pain threshold in tail-immersion test. Moreover, the extracts (200–400 mg/kg) also exhibited a dose-dependent inhibition of
writhing and also showed a significant (P<0.05) inhibition of both phases of the formalin induced pain test. The alcoholic extract
(200-400 mg/kg) significantly (P<0.05) reversed yeast-induced fever where as no significant result was obtained with water extract.
The results obtained in this study indicate that the extracts possess analgesic, anti-inflammatory and antipyretic properties. The
study seems to provide a rationale for the traditional use of this plant in pain, inflammation and pyrexia disorders.

Key words: Capparis zeylanica, alkaloids, analgesic, tannins, phenols