Asina Journal Of Traditional Medicines

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Antibacterial Activity Test of Coptis chinensis Alkaloids Combined with Moxifloxacin

Feng Xu 1, Lijie Zhao 2, Fan Che 1, Siyu Hu 1, Yu Chen 1, Huasong Liu 1, Wei Xu 1*, Feng Qiu 3*   

  1. 1 School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Teaching and Research Section of Health, Unit 95979 of Shenyang Military Area, Shenyang 110045, China; 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received:2015-11-13 Revised:2016-02-18 Online:2016-08-20 Published:2016-02-18
  • Contact: Feng Qiu: Address: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Tel: +86-24-23986463; E-mail: fengqiu2000@tom.com. Wei Xu: Address: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China; Tel: +86-24-23986702; E-mail: shxuwei8720@163.com.

Abstract: Coptis chinensis alkaloids are used as antimicrobial agents for a long time. This study was to investigate the potential antibacterial activity of alkaloids combinated with moxifloxacin. It was found that Coptis chinensis alkaloids combined with moxifloxacin had obviously synergistic bactericidal efficacy. The fractionary inhibitory concentration index (FICI) to Staphylococcus aureus [CMCC (B) 26003], Escherichia coli [CMCC (B) 44102] and Bacillus subtilis [CMCC (B) 63501] were 0.625, 0.75 and 0.05625, respectively. These results could lay the foundation of cutting down the wide use of chemical antimicrobials in the future.

Key words: Coptis chinensis alkaloids, moxifloxacin, checkerboard method

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